MCOLN2 |
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Identifiers |
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Aliases | MCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2 |
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External IDs | OMIM: 607399; MGI: 1915529; HomoloGene: 12258; GeneCards: MCOLN2; OMA:MCOLN2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p22.3 | Start | 84,925,583 bp[1] |
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End | 84,997,113 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 H2 | Start | 145,855,588 bp[2] |
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End | 145,901,268 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tibia
- cartilage tissue
- rectum
- mucosa of transverse colon
- lymph node
- right adrenal cortex
- mucosa of ileum
- granulocyte
- left adrenal gland
- secondary oocyte
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| Top expressed in | - Ileal epithelium
- yolk sac
- duodenum
- spleen
- stroma of bone marrow
- mesenteric lymph nodes
- jejunum
- colon
- embryo
- left colon
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - calcium channel activity
- cation channel activity
- NAADP-sensitive calcium-release channel activity
| Cellular component | - integral component of membrane
- membrane
- lysosome
- lysosomal membrane
- endosome
- plasma membrane
- late endosome membrane
- recycling endosome membrane
- recycling endosome
| Biological process | - ion transport
- adaptive immune response
- immune system process
- calcium ion transport
- protein transport
- innate immune response
- calcium ion transmembrane transport
- positive regulation of chemokine production
- protein complex oligomerization
- positive regulation of monocyte chemotactic protein-1 production
- positive regulation of macrophage inflammatory protein 1 alpha production
- positive regulation of chemokine (C-C motif) ligand 5 production
- macrophage migration
- neutrophil migration
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- release of sequestered calcium ion into cytosol
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 84.93 – 85 Mb | Chr 3: 145.86 – 145.9 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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