Protein-coding gene in humans
CACNA1G |
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Identifiers |
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Aliases | CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G, SCA42ND |
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External IDs | OMIM: 604065; MGI: 1201678; HomoloGene: 22544; GeneCards: CACNA1G; OMA:CACNA1G - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q21.33 | Start | 50,560,715 bp[1] |
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End | 50,627,474 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 D | Start | 94,299,217 bp[2] |
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End | 94,365,024 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - lateral nuclear group of thalamus
- right hemisphere of cerebellum
- right frontal lobe
- primary visual cortex
- cerebellar vermis
- endothelial cell
- prefrontal cortex
- orbitofrontal cortex
- dorsolateral prefrontal cortex
- testicle
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| Top expressed in | - cerebellar cortex
- medial dorsal nucleus
- superior frontal gyrus
- lobe of cerebellum
- neural layer of retina
- cerebellar vermis
- medial geniculate nucleus
- primary visual cortex
- lumbar subsegment of spinal cord
- lateral geniculate nucleus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - voltage-gated calcium channel activity
- calcium channel activity
- scaffold protein binding
- voltage-gated ion channel activity
- ion channel activity
- voltage-gated calcium channel activity involved in AV node cell action potential
- voltage-gated calcium channel activity involved SA node cell action potential
- low voltage-gated calcium channel activity
- voltage-gated sodium channel activity
| Cellular component | - integral component of membrane
- membrane
- voltage-gated calcium channel complex
- cytoplasm
- plasma membrane
| Biological process | - membrane depolarization during action potential
- calcium ion import
- regulation of membrane potential
- regulation of ion transmembrane transport
- regulation of atrial cardiac muscle cell membrane depolarization
- ion transport
- regulation of heart rate
- positive regulation of calcium ion-dependent exocytosis
- transmembrane transport
- action potential
- response to nickel cation
- calcium ion transport
- chemical synaptic transmission
- AV node cell to bundle of His cell signaling
- regulation of heart rate by cardiac conduction
- SA node cell action potential
- AV node cell action potential
- SA node cell to atrial cardiac muscle cell signaling
- membrane depolarization during AV node cell action potential
- calcium ion transmembrane transport
- membrane depolarization during SA node cell action potential
- cardiac muscle cell action potential involved in contraction
- neuronal action potential
- sodium ion transmembrane transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001256324 NM_001256325 NM_001256326 NM_001256327 NM_001256328
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NM_001256329 NM_001256330 NM_001256331 NM_001256332 NM_001256333 NM_001256334 NM_001256359 NM_001256360 NM_001256361 NM_018896 NM_198376 NM_198377 NM_198378 NM_198379 NM_198380 NM_198382 NM_198383 NM_198384 NM_198385 NM_198386 NM_198387 NM_198388 NM_198396 NM_198397 |
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NM_001112813 NM_001177888 NM_001177890 NM_009783 |
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RefSeq (protein) | NP_001243253 NP_001243254 NP_001243255 NP_001243256 NP_001243257
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NP_001243258 NP_001243259 NP_001243260 NP_001243261 NP_001243262 NP_001243263 NP_001243288 NP_001243289 NP_001243290 NP_061496 NP_938190 NP_938191 NP_938192 NP_938193 NP_938194 NP_938196 NP_938197 NP_938198 NP_938199 NP_938200 NP_938201 NP_938202 NP_938406 |
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Location (UCSC) | Chr 17: 50.56 – 50.63 Mb | Chr 11: 94.3 – 94.37 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene.[5][6][7] It is one of the primary targets in the pharmacology of absence seizure.
Function
Cav3.1 is a type of low-voltage-activated calcium channel, also known as "T-type" for its transient on and off.[5] It is expressed in thalamocortical relay nucleus, and is responsible for the slow-wave sleep and absence seizure.[8] During a slow-wave sleep, Cav3.1 is put into burst mode, and a self-sustaining synchronous cycle between cortex and thalamus is formed, sensory inputs are isolated from cortex; while awake the thalamus should instead relay sensory inputs from outside the central nervous system. The mechanism of absence seizure has a lot in common with slow-wave sleep. Therefore, a blocker that inhibits the burst mode activation of Cav3.1 is effective in treating absence seizures. Common drugs including ethosuximide, as well as trimethadione.[8]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]
[[File:
|alt=Nicotine Activity on Chromaffin Cells edit]]
Nicotine Activity on Chromaffin Cells edit
- ^ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
- ^ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.
- ^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.
- ^ a b Kopecky, Benjamin J.; Liang, Ruqiang; Bao, Jianxin (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". Pflügers Archiv. 466 (4): 757–765. doi:10.1007/s00424-014-1454-x. ISSN 0031-6768. PMC 4005039. PMID 24563219.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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