Protein-coding gene in humans
CACNA1I |
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Identifiers |
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Aliases | CACNA1I, Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I |
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External IDs | OMIM: 608230; MGI: 2178051; HomoloGene: 69331; GeneCards: CACNA1I; OMA:CACNA1I - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 22 (human)[1] |
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| Band | 22q13.1 | Start | 39,570,753 bp[1] |
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End | 39,689,735 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15|15 E1 | Start | 80,171,439 bp[2] |
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End | 80,282,480 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- primary visual cortex
- middle temporal gyrus
- Brodmann area 46
- entorhinal cortex
- Region I of hippocampus proper
- postcentral gyrus
- superior frontal gyrus
- glutes
- right frontal lobe
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| Top expressed in | - striatum of neuraxis
- olfactory bulb
- superior frontal gyrus
- visual cortex
- primary visual cortex
- cerebellum
- dentate gyrus of hippocampal formation granule cell
- cerebellar cortex
- hippocampus proper
- hypothalamus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - voltage-gated calcium channel activity
- calcium channel activity
- low voltage-gated calcium channel activity
- voltage-gated ion channel activity
- ion channel activity
- protein binding
- voltage-gated sodium channel activity
| Cellular component | - voltage-gated calcium channel complex
- integral component of membrane
- membrane
- plasma membrane
| Biological process | - flagellated sperm motility
- membrane depolarization during action potential
- calcium ion import
- regulation of ion transmembrane transport
- ion transport
- positive regulation of calcium ion-dependent exocytosis
- sleep
- calcium ion transmembrane transport
- transmembrane transport
- calcium ion transport
- signal transduction
- neuronal action potential
- sodium ion transmembrane transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 22: 39.57 – 39.69 Mb | Chr 15: 80.17 – 80.28 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.[5][6][7]
Function
Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
- ^ Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.
- ^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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