Protein-coding gene in the species Homo sapiens
CLIC6 |
---|
|
Identifiers |
---|
Aliases | CLIC6, CLIC1L, chloride intracellular channel 6 |
---|
External IDs | OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 21 (human)[1] |
---|
| Band | 21q22.12 | Start | 34,668,994 bp[1] |
---|
End | 34,718,227 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 16 (mouse)[2] |
---|
| Band | 16|16 C4 | Start | 92,282,624 bp[2] |
---|
End | 92,338,131 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - retinal pigment epithelium
- bronchial epithelial cell
- nasal epithelium
- caput epididymis
- palpebral conjunctiva
- epithelium of nasopharynx
- mucosa of paranasal sinus
- pancreatic epithelial cell
- olfactory zone of nasal mucosa
- pancreatic ductal cell
|
| Top expressed in | - Epithelium of choroid plexus
- epithelium of stomach
- retinal pigment epithelium
- olfactory epithelium
- ciliary body
- migratory enteric neural crest cell
- epithelium of small intestine
- yolk sac
- left colon
- efferent ductule
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - voltage-gated ion channel activity
- glutathione transferase activity
- chloride channel activity
- D2 dopamine receptor binding
- D3 dopamine receptor binding
- D4 dopamine receptor binding
| Cellular component | - integral component of membrane
- plasma membrane
- extracellular exosome
- membrane
- chloride channel complex
- nucleus
- cytoplasm
| Biological process | - regulation of ion transmembrane transport
- chloride transport
- ion transport
- glutathione metabolic process
- chloride transmembrane transport
- transport
- ion transmembrane transport
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 21: 34.67 – 34.72 Mb | Chr 16: 92.28 – 92.34 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]
The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]
Interactions
CLIC6 has been shown to interact with Dopamine receptor D3.[7]
Function
CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
- ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6".
- ^ Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- ^ Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.
Further reading
- Singh H (May 2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–2121. Bibcode:2010FEBSL.584.2112S. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
- Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome. 13 (8): 456–462. doi:10.1007/s00335-001-2157-0. hdl:11586/196820. PMID 12226712. S2CID 26059147.
- Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
- Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it. |