TAF1 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1EQF, 3AAD, 3UV4, 3UV5, 4RGW, 4YYM, 4YYN, 5I29, 5I1Q, 5FUR | | |
Ідентифікатори |
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Символи | TAF1, BA2R, CCG1, CCGS, DYT3, DYT3/KAT4, N-NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP, MRXS33, TATA-box binding protein associated factor 1 |
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Зовнішні ІД | OMIM: 313650 MGI: 1336878 HomoloGene: 37942 GeneCards: TAF1 |
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Пов'язані генетичні захворювання |
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X-linked dystonia-parkinsonism[1] |
Онтологія гена |
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Молекулярна функція | • transferase activity • nucleotide binding • DNA binding • GO:0001105 transcription coactivator activity • p53 binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • lysine-acetylated histone binding • TBP-class protein binding • acyltransferase activity • ATP binding • protein serine/threonine kinase activity • histone acetyltransferase activity • kinase activity • protein heterodimerization activity • H3K27me3 modified histone binding • ubiquitin conjugating enzyme activity • acetyl-CoA binding • sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II-specific DNA-binding transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000983 RNA polymerase II general transcription initiation factor activity |
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Клітинна компонента | • нуклеоплазма • MLL1 complex • клітинне ядро • ядерце • transcription regulator complex • transcription factor TFIID complex |
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Біологічний процес | • фосфорилювання • RNA polymerase II preinitiation complex assembly • transcription by RNA polymerase II • positive regulation of transcription initiation from RNA polymerase II promoter • transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • DNA-templated transcription, initiation • protein autophosphorylation • клітинний цикл • transcription initiation from RNA polymerase II promoter • peptidyl-threonine phosphorylation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of signal transduction by p53 class mediator • GO:0022415 viral process • histone acetylation • protein polyubiquitination • protein phosphorylation • cellular response to DNA damage stimulus • negative regulation of gene expression • midbrain development • positive regulation of protein binding • cellular response to UV • transcription factor catabolic process • protein stabilization • regulation of transcription initiation from RNA polymerase II promoter • cellular response to ATP • regulation of cell cycle G1/S phase transition • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding • negative regulation of protein autoubiquitination • negative regulation of ubiquitin-dependent protein catabolic process • positive regulation of androgen receptor activity • positive regulation of transcription by RNA polymerase I • GO:0009373 regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • negative regulation of DNA-binding transcription factor activity • ubiquitin-dependent protein catabolic process |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001286074 NM_004606 NM_138923 |
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RefSeq (білок) | | NP_001273003 NP_004597 NP_620278 |
| | NP_001277658 NP_001392888 NP_001392889 NP_001392890 NP_001392891 |
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Локус (UCSC) | Хр. X: 71.37 – 71.53 Mb | Хр. X: 100.58 – 100.65 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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