Suprofen
Non-steroidal anti-inflammatory drug
- M01AE07 (WHO)
- Discontinued
- (RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
- 40828-46-4 Y
- 5359
- 7298
- DB00870 Y
- 5166 N
- 988GU2F9PE
- D00452 Y
- CHEBI:9362 N
- ChEMBL956 N
- DTXSID5045469
- Interactive image
- O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2
InChI
- InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) N
- Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N N
Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.
Uses
Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]
References
- ^ DE 2353357, Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", issued 1974
- ^ Nies AS (1988). "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. Vol. 24. pp. 95–106. doi:10.1007/978-3-0348-9160-8_9 (inactive 2024-09-18). ISBN 978-3-0348-9931-4. PMID 3142236.
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ignored (help)CS1 maint: DOI inactive as of September 2024 (link) - ^ "Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. Archived from the original on 1 January 2009.
- ^ "Suprofen ophthalmic". Drugs.com. Archived from the original on 2021-09-09. Retrieved 2018-01-23.
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