Apricoxib
Chemical compound
- Investigational
- 4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide
- 197904-84-0
- 9820073
- DB12378
- 7995822
- 5X5HB3VZ3Z
- D08657
- DTXSID60173502
- Interactive image
- CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
InChI
- InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)
- Key:JTMITOKKUMVWRT-UHFFFAOYSA-N
Apricoxib is an experimental anticancer drug and nonsteroidal anti-inflammatory drug (NSAID).[1] It is a COX-2 inhibitor which is intended to improve standard therapy response in molecularly-defined models of pancreatic cancer.[2] It was also studied in clinical trials for non-small-cell lung cancer.[3] Development was abandoned in 2015 due to poor clinical trial results.[4]
See also
- Tilmacoxib
- Cimicoxib
- NS-398
- Celecoxib
References
- ^ "Apricoxib (Code C74021)". NCI Thesaurus. National Cancer Institute.
- ^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42. doi:10.1158/1078-0432.CCR-12-0453. PMC 3777527. PMID 22829202.
- ^ Edelman MJ, Tan MT, Fidler MJ, Sanborn RE, Otterson G, Sequist LV, et al. (January 2015). "Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer". Journal of Clinical Oncology. 33 (2): 189–94. doi:10.1200/JCO.2014.55.5789. PMC 4890680. PMID 25452446.
- ^ "Apricoxib". Adis Insight. Springer Nature Switzerland AG.
- v
- t
- e
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor |
| ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
EP (E2)Tooltip Prostaglandin E2 receptor |
| ||||||||||
FP (F2α)Tooltip Prostaglandin F receptor |
| ||||||||||
IP (I2)Tooltip Prostacyclin receptor |
| ||||||||||
TP (TXA2)Tooltip Thromboxane receptor |
| ||||||||||
Unsorted |
|
(inhibitors)
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
- See also
- Receptor/signaling modulators
- Leukotriene signaling modulators
This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e