Diacetolol

Chemical compound

Pharmacokinetic dataElimination half-life8-13 hoursIdentifiers

CAS Number

PubChem CID

ChemSpider

UNII

ChEMBL

CompTox Dashboard (EPA)

ECHA InfoCard100.040.974

Chemical and physical dataFormulaC₁₆H₂₄N₂O₄Molar mass308.378 g·mol⁻¹3D model (JSmol)

InChI

InChI=1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)^Y
Key:AWOGXJOBNAWQSF-UHFFFAOYSA-N^Y

(verify)

Diacetolol is the primary metabolite of acebutolol. It is a beta blocker and anti-arrhythmic agent.^[1]

References

^ Basil B, Jordan R (May 1982). "Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol". European Journal of Pharmacology. 80 (1): 47–56. doi:10.1016/0014-2999(82)90176-5. PMID 6124437.

Sympatholytic (and closely related) antihypertensives (C02)

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan, Bosentan, Macitentan (+tadalafil)) selective (Ambrisentan, Sitaxentan)