Naphazoline
- R01AA08 (WHO) S01GA01 (WHO)
- In general: Over-the-counter (OTC)
- 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
- 835-31-4 N
- 4436
- 5509
- DB06711 Y
- 4283 Y
- H231GF11BV
- D08253 Y
- ChEMBL761 Y
- DTXSID3048449
- Interactive image
- N\1=C(\NCC/1)Cc2cccc3c2cccc3
- InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16) Y
- Key:CNIIGCLFLJGOGP-UHFFFAOYSA-N Y
Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid action in reducing swelling when applied to mucous membranes. It is a sympathomimetic agent with marked alpha adrenergic activity that acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.
It was patented in 1934 and came into medical use in 1942.[1]
Medical uses
Nasal administration
Nasal decongestant.[2]
Ophthalmic drug administration
Eye drops (brand names Clear Eyes, and Cleari) narrowing swollen blood vessels (ophthalmic arteries, and ophthalmic veins) to relieve red eye.[2]
Temporary red eye can safely be treated when the cause of the redness is established (e.g. cannabis induced corneal vasodilation).[3] However, continuous use is not recommended without knowing an underlying condition.
Side effects
A few warnings and contraindications that apply to all naphazoline-containing substances intended for medicinal use are:
- Hypersensitivity to naphazoline
- Use in infants and children can result in central nervous system depression, leading to coma and marked reduction in body temperature
- Should be used with caution in patients with severe cardiovascular disease including cardiac arrhythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis
- A possible association with stroke has been suggested.[4]
Nasal administration
- Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion.
Ophthalmic drug administration
Known side-effect:[5][6]
- Stinging
- Discomfort
- Irritation
- Increased red eyes
- Blurred vision
- Mydriasis
- Punctate keratitis
- Lacrimation (tears)
- Increased intraocular pressure
Contraindications
- Patients taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl
- Drug interactions can occur with anaesthetics that sensitize the myocardium to sympathomimetics (e.g. cyclopropane or halothane cautiously)
- Exercise caution when applying prior to use of phenylephrine.
Pharmacology
Naphazoline is a mixed α1- and α2-adrenergic receptor agonist.[2]
Chemistry
The non-hydrochloride form of Naphazoline has the molecular formula C14H14N2 and a molar mass of 210.28 g/mol. The HCl salt form has a molar mass of 246.73 g/mol.
Society and culture
It is an active ingredient in several over-the-counter eye drop formulations including Clear Eyes, Rohto, Eucool, and Naphcon-A.[7]
Illicit use
The nasal or ophthalmic form of naphazoline has been abused by heroin or cocaine drug addicts.[8][9] It's used as CNS stimulant and vasoconstrictor to enhance primary drug effects.[9]
References
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 552. ISBN 9783527607495.
- ^ a b c Hosten LO, Snyder C (2020). "Over-the-Counter Ocular Decongestants in the United States - Mechanisms of Action and Clinical Utility for Management of Ocular Redness". Clinical Optometry. 12: 95–105. doi:10.2147/OPTO.S259398. PMC 7399465. PMID 32801982.
- ^ Yazulla S (September 2008). "Endocannabinoids in the retina: from marijuana to neuroprotection". Progress in Retinal and Eye Research. 27 (5): 501–526. doi:10.1016/j.preteyeres.2008.07.002. PMC 2584875. PMID 18725316.
- ^ Zavala JA, Pereira ER, Zétola VH, Teive HA, Nóvak EM, Werneck LC (September 2004). "Hemorrhagic stroke after naphazoline exposition: case report". Arquivos de Neuro-Psiquiatria. 62 (3B): 889–891. doi:10.1590/S0004-282X2004000500030. PMID 15476091.
- ^ "Naphazoline - FDA prescribing information, side effects and uses". Drugs.com.
- ^ "naphazoline ophthalmic (eye): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com.
- ^ Green SM (2008). "Ophthalmology: Naphazoline". Tarascon Pocket Pharmacopoeia 2009. Jones and Bartlett. ISBN 978-0-7637-6572-9.
- ^ van Montfrans GA, van Steenwijk RP, Vyth A, Borst C (1981). "Intravenous naphazoline intoxication". Acta Medica Scandinavica. 209 (5): 429–430. doi:10.1111/j.0954-6820.1981.tb11622.x. PMID 7246278.
- ^ a b "Naphazoline abuse". Reactions Weekly. 1815 (1): 251. 2020-08-01. doi:10.1007/s40278-020-81577-1. ISSN 1179-2051. S2CID 195174995.
- v
- t
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Sympathomimetics, plain | |
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Antiallergic agents, excluding corticosteroids | |
Corticosteroids | |
Other nasal preparations | |
Combination products |
Sympathomimetics
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III