A-349,821
IUPAC ime | |
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(4'-[3-(2R,5R-dimetilpirolidin-1-il)propoksi]bifenil-4-il)morfolin-4-ilmetanon | |
Identifikatori | |
CAS broj | 372513-99-0 Y |
ATC kod | none |
PubChem | CID 9954017 |
IUPHAR/BPS | 1217 |
ChemSpider | 8129627 Y |
ChEMBL | CHEMBL179702 Y |
Hemijski podaci | |
Formula | C26H34N2O3 |
Molarna masa | 422,558 |
SMILES
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InChI
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A-349,821 je potentan i selektivan antagonist histaminskog H3 receptora[1] (a verovatno i inverzni agonist).[2] Pokazano je da ima nootropno dejstvo u životinjskim studijama.[3] Ovo jedinjenje se koristi u laboratorijskim istraživanjima.
Reference
- ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K; Bennani, YL (2003). „Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists”. Bioorganic & Medicinal Chemistry Letters. 13 (7): 1325—8. PMID 12657274. doi:10.1016/S0960-894X(03)00118-5.
- ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW; Esbenshade, TA (2006). „Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand”. British Journal of Pharmacology. 148 (5): 657—70. PMC 1751875 . PMID 16715122. doi:10.1038/sj.bjp.0706752.
- ^ Esbenshade, TA; Fox, GB; Krueger, KM; Baranowski, JL; Miller, TR; Kang, CH; Denny, LI; Witte, DG; Yao, BB (2004). „Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist”. Biochemical pharmacology. 68 (5): 933—45. PMID 15294456. doi:10.1016/j.bcp.2004.05.048.
Vidi još
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VMAT |
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HDC | |
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HNMT | |
DAO | Inhibitori: Aminoguanidin |
Endogeni | Histamin; Prekursori: L-Histidin; Kofaktori: Vitamin B6 |
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A-349,821 на Викимедијиној остави.