Levodropropizine

Chemical compound

R05DB27 (WHO)

Pharmacokinetic dataProtein binding11-14%Excretion83% via urine within 96 hIdentifiers

IUPAC name

(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

CAS Number

99291-25-5^Y

PubChem CID

65859

DrugBank

DB12472^Y

ChemSpider

59270^Y

UNII

3O31P6T4G3

KEGG

D08119^Y

ChEBI

CHEBI:82722^N

CompTox Dashboard (EPA)

DTXSID8023210

ECHA InfoCard100.167.719

Chemical and physical dataFormulaC₁₃H₂₀N₂O₂Molar mass236.315 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

O[C@@H](CN2CCN(c1ccccc1)CC2)CO

InChI

InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1^Y
Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N^Y

^NY (what is this?) (verify)

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.^[1] It does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.

In September 2021, Korea United Pharm file lawsuits against 15 drug manufacturers as patent infringement protection for its 2017 registered antitussive drug Levotics CR Tab. (levodropropizine). The cases are anchored on violation of its patent for "Method for Preparing Sustained-Release Tablets Containing Levodropropizine."^[2] In September 2023, KUP signed a five-year $52.1 million contract with MCQ, a Thai-based pharmaceutical company, for supply of its mucoactive drug, Levotics CR Tab (levodropropizine).^[3]

External links

Levodropropizine - Monthly Index of Medical Specialities

References

^ De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012). "An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome". Cough. 8 (1): 1. doi:10.1186/1745-9974-8-1. PMC 3274450. PMID 22269875.
^ Chan-hyuk, Kim (September 9, 2021). "Korea United Pharm sues 15 drugmakers to protect cough suppressant's patent". Korea Biomedical Review. Retrieved July 29, 2024.
^ "Korea United Pharm to supply mucoactive drugs worth $52 million to Thailand". Korea Biomedical Review. September 9, 2023. Retrieved July 29, 2024.