Antihypertensive drug of the calcium channel blocker class
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Legal status | - In general: ℞ (Prescription only)
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Pharmacokinetic data |
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Bioavailability | ~10% |
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Protein binding | >95% |
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Metabolism | Hepatic |
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Onset of action | 30–50 min |
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Elimination half-life | 13–19 hours |
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Excretion | Feces (~70%) |
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Identifiers |
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Diethyl 4-{o-[(E)-2-tert-butoxycarbonylethenyl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
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PubChem CID | |
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UNII | |
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KEGG | - D04657 Y
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CompTox Dashboard (EPA) | - DTXSID1046429
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ECHA InfoCard | 100.166.373 |
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Chemical and physical data |
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Formula | C26H33NO6 |
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Molar mass | 455.551 g·mol−1 |
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3D model (JSmol) | |
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InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+ Key:GKQPCPXONLDCMU-CCEZHUSRSA-N |
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Lacidipine (tradenames Lacipil or Motens) is a calcium channel blocker. It is available as tablets containing 2 or 4 mg.
It was patented in 1984 and approved for medical use in 1991.[1]
References
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 466. ISBN 9783527607495.
External links
Calcium | VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium | VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | Blockers | |
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Activators | - GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium | VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride | CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others | TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators |