DEDD
DEDD | |||||||||||||||||||||||||
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别名 | DEDD;, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing | ||||||||||||||||||||||||
外部ID | OMIM:606841 MGI:1333874 HomoloGene:7980 GeneCards:DEDD | ||||||||||||||||||||||||
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物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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mRNA序列 |
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蛋白序列 |
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基因位置(UCSC) | Chr 1: 161.12 – 161.13 Mb | Chr 1: 171.16 – 171.17 Mb | |||||||||||||||||||||||
PubMed查找 | [3] | [4] | |||||||||||||||||||||||
維基數據 | |||||||||||||||||||||||||
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含死亡效应结构域蛋白(英語:Death effector domain containing protein)是人类中由DEDD基因编码的蛋白质。[5][6][7]
功能
该基因编码含有死亡效应结构域(DED)的蛋白质。DED是程序性细胞死亡途径的衔接子、调节子和执行子共享的蛋白质相互作用域。该基因的过度表达被证明可诱导微弱的细胞凋亡。在刺激作用下,发现该蛋白从细胞质易位到细胞核,并与UBTF共定位在核仁中,UBTF是RNA聚合酶I转录所需的基础因子。该基因至少有三种编码相同蛋白质的转录变体。[8]
相互作用
DEDD已被证明可以与以下基因产生相互作用:
- CFLAR[9][10]
- 胱天蛋白酶8[9][11][12]
- FADD[5][10]
参考资料
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ 5.0 5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
- ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .
- ^ Entrez Gene: DEDD death effector domain containing. [2024-03-15]. (原始内容存档于2010-12-05).
- ^ 引用错误:没有为名为
entrez2
的参考文献提供内容 - ^ 9.0 9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
- ^ 10.0 10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .
- ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
- ^ Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
延伸阅读
- Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 .
- Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
- Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 . PMID 12235123. doi:10.1083/jcb.200112124.
- Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
- Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 .
- Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .