CDKN2A |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E | | |
Ідентифікатори |
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Символи | CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF. |
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Зовнішні ІД | OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A |
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Пов'язані генетичні захворювання |
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melanoma-pancreatic cancer syndrome, mucosal melanoma, меланома, familial atypical multiple mole melanoma syndrome[1] |
Онтологія гена |
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Молекулярна функція | • NF-kappaB binding • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding • RNA binding • DNA binding • p53 binding • transcription factor binding • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity • disordered domain specific binding • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity |
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Клітинна компонента | • цитоплазма • гіалоплазма • senescence-associated heterochromatin focus • клітинне ядро • ядерні тільця • нуклеоплазма • ядерце • мітохондрія • GO:0009327 protein-containing complex |
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Біологічний процес | • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1 phase • negative regulation of cell-matrix adhesion • клітинне старіння • negative regulation of cell growth • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • клітинний цикл • Ras protein signal transduction • negative regulation of phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell population proliferation • G1/S transition of mitotic cell cycle • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • GO:0097285 апоптоз • regulation of G2/M transition of mitotic cell cycle • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • protein stabilization • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • autophagy of mitochondrion • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • protein sumoylation • GO:1901313 positive regulation of gene expression • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity • amyloid fibril formation • negative regulation of protein neddylation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_000077 NM_001195132 NM_058195 NM_058196 NM_058197
| NM_001363763 |
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RefSeq (білок) | NP_000068 NP_001182061 NP_478102 NP_478104 NP_001350692
| NP_478102.2 |
| | NP_001035744 NP_034007 NP_034007.1 |
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Локус (UCSC) | Хр. 9: 21.97 – 22 Mb | Хр. 4: 89.19 – 89.21 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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