BDNF |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1BND, 1B8M | | |
Ідентифікатори |
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Символи | BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor |
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Зовнішні ІД | OMIM: 113505 MGI: 88145 HomoloGene: 7245 GeneCards: BDNF |
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Пов'язані генетичні захворювання |
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ожиріння[1] |
Онтологія гена |
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Молекулярна функція | • signaling receptor binding • neurotrophin TRKB receptor binding • growth factor activity • GO:0001948, GO:0016582 protein binding |
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Клітинна компонента | • цитоплазма • perinuclear region of cytoplasm • мітохондрія • nuclear speck • GO:0016023 cytoplasmic vesicle • extracellular region • міжклітинний простір • Синаптичні бульбашки • аксон • дендрит (нейробіологія) |
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Біологічний процес | • brain-derived neurotrophic factor receptor signaling pathway • GO:1904089 negative regulation of neuron apoptotic process • synapse assembly • cell-cell signaling • positive regulation of brain-derived neurotrophic factor receptor signaling pathway • collateral sprouting • positive regulation of synapse assembly • positive regulation of collateral sprouting • нейробіологія розвитку • axon guidance • negative regulation of myotube differentiation • positive regulation of receptor binding • regulation of protein localization to cell surface • regulation of signaling receptor activity • activation of phospholipase C activity • neurotrophin TRK receptor signaling pathway • positive regulation of non-membrane spanning protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase signaling pathway • peripheral nervous system development • пам'ять • nerve development • nerve growth factor signaling pathway • regulation of neuron differentiation • neuron projection morphogenesis • modulation of chemical synaptic transmission • positive regulation of neuron projection development • negative regulation of apoptotic signaling pathway |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001143805 NM_001143806 NM_001143807 NM_001143808 NM_001143809
| NM_001143810 NM_001143811 NM_001143812 NM_001143813 NM_001143814 NM_001143815 NM_001143816 NM_001709 NM_170731 NM_170732 NM_170733 NM_170734 NM_170735 |
| NM_001048139 NM_001048141 NM_001048142 NM_007540 NM_001285416
| NM_001285417 NM_001285418 NM_001285419 NM_001285420 NM_001285421 NM_001285422 NM_001316310 |
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RefSeq (білок) | NP_001137277 NP_001137278 NP_001137279 NP_001137280 NP_001137281
| NP_001137282 NP_001137283 NP_001137284 NP_001137285 NP_001137286 NP_001137288 NP_001700 NP_733927 NP_733928 NP_733929 NP_733930 NP_733931 |
| NP_001041604 NP_001041606 NP_001041607 NP_001272345 NP_001272346
| NP_001272347 NP_001272348 NP_001272349 NP_001272350 NP_001272351 NP_001303239 NP_031566 |
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Локус (UCSC) | Хр. 11: 27.65 – 27.72 Mb | Хр. 2: 109.51 – 109.56 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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