- Air Miami (disbanded)
- The Amps (disbanded)
- A.R. Kane (disbanded)
- Tom Baril (photographer published by 4AD)
- Bauhaus (disbanded)
- Bearz (active)
- Beirut (active)
- Belly (disbanded)
- Heidi Berry (inactive; currently a teacher)
- Bettie Serveert (active)
- The Birthday Party (disbanded)
- Frank Black (active)
- The Breeders (active)
- Broken Records (active)
- Michael Brook (active)
- Harold Budd/Elizabeth Fraser/Robin Guthrie/Simon Raymonde
- The Bulgarian State Television Female Vocal Choir (active)
- Celebration (active)
- Clan of Xymox (active)
- Cocteau Twins (disbanded)
- Colourbox (dissolved)
- Cuba (a.k.a. Air Cuba) (disbanded)
- Cupol (one-off collaboration)
- C.V.O. (disbanded)
- Dance Chapter (disbanded)
- Dead Can Dance (active)
- Department of Eagles (active)
- Dif Juz (dissolved)
- Tanya Donelly (active)
- Electricity in Our Homes (active)
- The Fast Set (disbanded)
- 50 Foot Wave (active)
- Frazier Chorus (dissolved)
- Future of the Left (active)
- Lisa Germano (active)
- Lisa Gerrard & Pieter Bourke
- B. C. Gilbert & G. Lewis
| - The Glee Club (disbanded)
- Rachel Goswell (inactive)
- GusGus (active)
- Rene Halkett & David J
- Neil Halstead (active)
- Kristin Hersh (active)
- His Name Is Alive (active)
- The Hope Blister (disbanded)
- Rowland S. Howard & Lydia Lunch
- In Camera (disbanded)
- Insides (disbanded)
- It Hugs Back (active)
- Jóhann Jóhannsson (active)
- Matt Johnson
- Lakuna (one-off project)
- Last Dance (disbanded)
- The Late Cord (one-off, thus far, collaboration)
- Liquorice
- Lydia Lunch (active)
- Lush (disbanded)
- M|A|R|R|S (dissolved)
- Mass (disbanded)
- Vinny Miller (active)
- Minotaur Shock (active)
- Modern English (active)
- Magnetophone (active)
- Mojave 3 (on hiatus)
- The Mountain Goats (active)
- My Captains (disbanded)
- Colin Newman (active)
- Pieter Nooten/Michael Brook
- The Paladins (on hiatus)
- Pale Saints (disbanded)
- The Past 7 Days (disbanded)
- Brendan Perry (active)
| - Piano Magic (active)
- Pixies (active)
- Emma Pollock (active)
- Psychotik Tanks (disbanded)
- Ra Ra Riot (one-off split single with Stornoway)
- Red Atkins (active)
- Red House Painters (disbanded)
- Rema-Rema (disbanded)
- Richenel (active)
- Anni Rossi (active)
- Scheer (disbanded)
- Serena-Maneesh (active)
- Shox (disbanded)
- Kendra Smith (inactive)
- Sort Sol (on hiatus)
- Spasmodic Caress (disbanded)
- Spirea X (disbanded)
- Spoonfed Hybrid (disbanded)
- Starry Smooth Hound (the original alias of Vinny Miller)
- Stereolab (on hiatus)
- Swallow (disbanded)
- Sybarite (active)
- Tarnation (disbanded)
- that dog. (disbanded)
- The The (active)
- Thievery Corporation (active)
- This Mortal Coil (project concluded)
- Throwing Muses (active)
- Tindersticks (active)
- Tones on Tail (disbanded)
- TV on the Radio (active)
- 23 Envelope (4AD's design regulars in the '80s/'90s; now v23)
- Ultra Vivid Scene (disbanded)
- Underground Lovers (disbanded)
- Unrest (disbanded)
- Vaughan Oliver & v23 (active)
- M Ward (active)
- Wolf & Cub (active)
- The Wolfgang Press (disbanded)
- Xmal Deutschland (disbanded)
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