Ikatibant
Klinički podaci | |
---|---|
Drugs.com | Monografija |
Način primene | Subkutano |
Farmakokinetički podaci | |
Poluvreme eliminacije | 1,4 ± 0,4 h |
Izlučivanje | Urin (<10% nepromenjen) |
Identifikatori | |
CAS broj | 130308-48-4 Y |
ATC kod | B06AC02 (WHO) |
PubChem | CID 71364 |
DrugBank | DB06196 Y |
ChemSpider | 64461 Y |
ChEBI | CHEBI:68564 Y |
ChEMBL | CHEMBL1743581 Y |
Hemijski podaci | |
Formula | C59H89N19O13S |
Molarna masa | 1304,522 |
SMILES
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InChI
| |
Ikatibant je organsko jedinjenje, koje sadrži 59 atoma ugljenika i ima molekulsku masu od 1304,522 Da.[1][2][3][4]
Osobine
Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 23 |
Broj donora vodonika | 15 |
Broj rotacionih veza | 30 |
Particioni koeficijent[5] (ALogP) | -6,7 |
Rastvorljivost[6] (logS, log(mol/L)) | -9,0 |
Polarna površina[7] (PSA, Å2) | 552,0 |
Reference
- ^ Cockcroft JR, Chowienczyk PJ, Brett SE, Bender N, Ritter JM: Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist. Br J Clin Pharmacol. 1994 Oct;38(4):317-21. PMID 7833220
- ^ Bork K, Frank J, Grundt B, Schlattmann P, Nussberger J, Kreuz W: Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). J Allergy Clin Immunol. 2007 Jun;119(6):1497-503. Epub 2007 Apr 5. PMID 17418383
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Icatibant
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