CHST2

CHST2
Identifikatori
AlijasiCHST2
Spoljašnji IDOMIM: 603798 MGI: 1891160 HomoloGene: 3150 GeneCards: CHST2
Genska lokacija (miš)
Chromosome 9 (mouse)
Hr.Chromosome 9 (mouse)[1]
Chromosome 9 (mouse)
Genomska lokacija za CHST2
Genomska lokacija za CHST2
Band9|9 E3.3Start95,281,345 bp[1]
Kraj95,288,775 bp[1]
Obrazac RNK izražavanja
More reference expression data
Genska ontologija
Molecular function• transferase activity
• sulfotransferase activity
• N-acetylglucosamine 6-O-sulfotransferase activity
Cellular component• саставни део мембране
• Golgi membrane
• trans-Golgi network
• intrinsic component of Golgi membrane
• мембрана
• Голџијев апарат
Biological process• multicellular organism development
• sulfur compound metabolic process
• запаљенска реакција
• keratan sulfate biosynthetic process
• N-acetylglucosamine metabolic process
• Метаболизам угљених хидрата
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

9435

54371

Ensembl

ENSG00000175040

ENSMUSG00000033350

UniProt

Q9Y4C5

Q80WV3

RefSeq (mRNA)

NM_004267

NM_018763

RefSeq (protein)

NP_004258

NP_061233

Location (UCSC)n/aChr 9: 95.28 – 95.29 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Ugljeno hidratna sulfotransferaza 2 je enzim koji je kod ljudi kodiran genom CHST2[4][5], nalazi se na kratkom (p) kraku 3. hromozoma. Dužina polipeptidnog lanca proteina je 530 aminokiselina, a molekulska težina 57.857.7[6]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000033350 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Li X, Tedder TF (мај 1999). „CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization”. Genomics. 55 (3): 345—7. PMID 10049591. doi:10.1006/geno.1998.5653. CS1 одржавање: Формат датума (веза)
  5. ^ „Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2”. 
  6. ^ „UniProt, Q9Y4C5” (на језику: eng.). Архивирано из оригинала 29. 01. 2018. г. Приступљено 07. 06. 2024. CS1 одржавање: Непрепознат језик (веза)

Dopunska literatura

  • Bernstein HB, Compans RW (1992). „Sulfation of the human immunodeficiency virus envelope glycoprotein.”. J. Virol. 66 (12): 6953—9. PMC 240329 Слободан приступ. PMID 1433500. doi:10.1128/JVI.66.12.6953-6959.1992. 
  • Shilatifard A, Merkle RK, Helland DE, et al. (1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.”. J. Virol. 67 (2): 943—52. PMC 237448 Слободан приступ. PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993. 
  • Uchimura K, Muramatsu H, Kadomatsu K, et al. (1998). „Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase.”. J. Biol. Chem. 273 (35): 22577—83. PMID 9712885. doi:10.1074/jbc.273.35.22577 Слободан приступ. 
  • Uchimura K, Muramatsu H, Kaname T, et al. (1998). „Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells.”. J. Biochem. 124 (3): 670—8. PMID 9722682. doi:10.1093/oxfordjournals.jbchem.a022164. 
  • Tu L, Murphy PG, Li X, Tedder TF (1999). „L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.”. J. Immunol. 163 (9): 5070—8. PMID 10528213. doi:10.4049/jimmunol.163.9.5070 Слободан приступ. 
  • Sakaguchi H, Kitagawa H, Sugahara K (2000). „Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence.”. Biochim. Biophys. Acta. 1523 (2–3): 269—76. PMID 11042394. doi:10.1016/s0304-4165(00)00136-7. 
  • Okuda T, Mita S, Yamauchi S, et al. (2001). „Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.”. J. Biochem. 128 (5): 763—70. PMID 11056388. doi:10.1093/oxfordjournals.jbchem.a022813. 
  • Li X, Tu L, Murphy PG, et al. (2001). „CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.”. J. Leukoc. Biol. 69 (4): 565—74. PMID 11310842. S2CID 8888883. doi:10.1189/jlb.69.4.565 Слободан приступ. 
  • Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). „Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.”. J. Biol. Chem. 277 (6): 3979—84. PMID 11726653. doi:10.1074/jbc.M106587200 Слободан приступ. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Grunwell JR, Rath VL, Rasmussen J, et al. (2003). „Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases.”. Biochemistry. 41 (52): 15590—600. PMID 12501187. doi:10.1021/bi0269557. 
  • de Graffenried CL, Bertozzi CR (2003). „Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.”. J. Biol. Chem. 278 (41): 40282—95. PMID 12855678. doi:10.1074/jbc.M304928200 Слободан приступ. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285 Слободан приступ. 
  • de Graffenried CL, Bertozzi CR (2004). „The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.”. J. Biol. Chem. 279 (38): 40035—43. PMID 15220337. doi:10.1074/jbc.M405709200 Слободан приступ. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Chen L, Ichihara-Tanaka K, Muramatsu T (2005). „Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1.”. J. Biochem. 136 (5): 659—64. PMID 15632306. doi:10.1093/jb/mvh162. 
  • Kanoh A, Seko A, Ideo H, et al. (2007). „Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas.”. Glycoconj. J. 23 (5–6): 453—60. PMID 16897186. S2CID 22628478. doi:10.1007/s10719-006-6979-6. 
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