AMG-36
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(IUPAC) ime | |||
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(6aR,10aR)-3-(1-heksilciklopentil)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | ? | ||
PubChem[1][2] | 10982174 | ||
ChemSpider[3] | 9157375 | ||
ChEMBL[4] | CHEMBL108868 ![]() | ||
Hemijski podaci | |||
Formula | C27H40O2 | ||
Mol. masa | 396,.604 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
AMG-36 je analgetik koji je kanabinoidni agonist. On je derivat Δ8THC koji je supstituisan sa ciklopentanskom grupom u 3-poziciji bočnog lanca. AMG-36 je potentan agonist na CB1 i CB2 sa umerenom selektivnošću za CB1, pri čemu je Ki 0,4 nM na CB1 vs 1,9 nM na CB2.[5][6]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
- ↑ Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444
Šablon:Kanabinoidi