COX-3

COX-3 é uma recente descoberta de isoforma de ciclo-oxigenase, encontrada no cérebro, medula espinhal e coração. A estrutura química corresponde a da COX-1, exceto pelo íntron 1.[1]

Foi sugerida por Daniel L. Simmons e sua equipe e acredita-se que este tipo esteja presente no sistema nervoso central devido os efeitos do paracetamol (provável inibidor mais seletivo desta forma) e não tanto de COX-2 e COX-1 na periferia.[2]

Modula a dor e febre no SNC

Notas e referências

  1. ↑ Guía farmacológica de analgésicos
  2. ↑ SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

Leitura adicional

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