CXCL7 |
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Struktur sedia ada |
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PDB | Pencarian ortolog: PDBe RCSB |
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Senarai kod PDB |
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1TVX, 1F9P, 1NAP |
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Pengecam |
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Alias | PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein |
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Pengecam-pengecam luaran | OMIM: 121010 MGI: 1888712 HomoloGene: 136759 GeneCards: PPBP |
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Kedudukan gen (Manusia) |
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| Kr. | Kromosom 4[1] |
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| Jalur | 4q13.3 | Mula | 73,986,439 bp[1] |
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Tamat | 73,988,190 bp[1] |
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Corak ekspresi RNA |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- trabecular bone
- granulocyte
- darah
- bone marrow cells
- periodontal fiber
- limpa
- decidua
- right lung
- Testis
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| Top expressed in | - tibiofemoral joint
- Tali pusat
- darah
- limpa
- fetal liver hematopoietic progenitor cell
- body of femur
- right lung lobe
- janin
- endocardial cushion
- Kantung yolka
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| More reference expression data |
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BioGPS | | Rujukan lanjutan untuk data ekspresi |
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Ontologi gen |
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Fungsi molekul | - growth factor activity
- cytokine activity
- glucose transmembrane transporter activity
- CXCR chemokine receptor binding
- chemokine activity
- Pengikatan protein plasma
| Komponen sel | - platelet alpha granule lumen
- extracellular region
- Ekstrasel
- tertiary granule lumen
- platelet alpha granule
| Proses biologi | - response to lipopolysaccharide
- regulation of cell population proliferation
- chemotaxis
- positive regulation of cell division
- platelet degranulation
- defense response to bacterium
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- defense response
- positive regulation of neutrophil chemotaxis
- antimicrobial humoral immune response mediated by antimicrobial peptide
- regulation of signaling receptor activity
- neutrophil degranulation
- cell chemotaxis
- G protein-coupled receptor signaling pathway
- glucose transmembrane transport
- neutrophil chemotaxis
- leukocyte chemotaxis
- cellular response to lipopolysaccharide
| Sumber:Amigo / QuickGO |
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Ortolog |
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Spesies | Manusia | Mencit |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Kedudukan (UCSC) | Chr 4: 73.99 – 73.99 Mb | tiada data |
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Carian PubMed | [2] | [3] |
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Wikidata |
Papar/Sunting data manusia | Papar/Sunting data mencit |
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Ligan kemokin (motif C-X-C) 7 (CXCL7) ialah gen manusia.[4] Protein terkod itu ialah sitokina kecil yang tergolong dalam keluarga kemokina CXC dan merupakan salah satu isobentuk protein Beta-Tromboglobulin atau protein asas pro-platelet (PPBP).[5]
CXCL7 ialah protein yang dibebaskan pada jumlah yang besar oleh platelet, selepas pengaktifannya.[6] Ia merangsangkan berbagai-bagai proses, termasuk: [7][8]
- mitogenesis;
- metabolisme glukosa;
- sintesis matriks luar sel; dan
- sinthesis pengaktif plasminogen.
Rujukan
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163736 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)".
- ^ Hristov M, Zernecke A, Bidzhekov K; dll. (2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812. Unknown parameter
|month=
ignored (bantuan); Explicit use of et al. in: |author=
(bantuan)CS1 maint: multiple names: authors list (link) - ^ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785–9. PMID 1826003.CS1 maint: multiple names: authors list (link)
- ^ Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMID 6572368.CS1 maint: multiple names: authors list (link)
- ^ Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.CS1 maint: multiple names: authors list (link)
Galeri PDB |
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Templat:PDB Gallery/5473 |
Pengisyaratan sel: sitokin |
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Mengikut keluarga | Kemokin | CCL | - CCL1
- CCL2/MCP1
- CCL3/MIP1α
- CCL4/MIP1β
- CCL5/RANTES
- CCL6
- CCL7
- CCL8
- CCL9
- CCL11
- CCL12
- CCL13
- CCL14
- CCL15
- CCL16
- CCL17
- CCL18/PARC/DCCK1/AMAC1/MIP4
- CCL19
- CCL20
- CCL21
- CCL22
- CCL23
- CCL24
- CCL25
- CCL26
- CCL27
- CCL28
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CXCL | - CXCL1/KC
- CXCL2
- CXCL3
- CXCL4
- CXCL5
- CXCL6
- CXCL7
- CXCL8/IL8
- CXCL9
- CXCL10
- CXCL11
- CXCL12
- CXCL13
- CXCL14
- CXCL15
- CXCL16
- CXCL17
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CX3CL | |
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XCL | |
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TNF | - TNFA
- Limfotoksin
- TNFSF4
- TNFSF5/CD40LG
- TNFSF6
- TNFSF7
- TNFSF8
- TNFSF9
- TNFSF10
- TNFSF11
- TNFSF13
- TNFSF13B
- EDA
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Interleukin | Jenis I (pengelasan mengikut subunit reseptor) | Rantai γ | - IL2/IL15
- IL4/IL13
- IL7
- IL9
- IL21
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Rantai β | |
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Seperti IL6/gp130 | - IL6
- IL11
- IL27
- IL30
- IL31
- +OSM bukan IL
- LIF
- CNTF
- CTF1
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Keluarga IL12/IL12RB1 | |
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Lain-lain | |
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Jenis II | Keluarga IL10 | - IL10/IL22
- IL19
- IL20
- IL24
- IL26
- Interferon jenis III
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Interferon | I | - IFNA1
- IFNA2
- IFNA4
- IFNA5
- IFNA6
- IFNA7
- IFNA8
- IFNA10
- IFNA13
- IFNA14
- IFNA16
- IFNA17
- IFNA21
- IFNB1
- IFNK
- IFNW1
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II | |
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Superkeluarga Ig | - Keluarga IL1: IL1A/IL1F1
- IL1B/IL1F2
- 1Ra/IL1F3
- IL1F5
- IL1F6
- IL1F7
- IL1F8
- IL1F9
- IL1F10
- 33/IL1F11
- 18/IL1G
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Keluarga IL17 | |
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Lain-lain | - Hematopoiesis
- KITLG
- Faktor perangsang koloni
- SPP1
- MIF
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Mengikut fungsi/ sel | |
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Templat:Pemodulat reseptor kemokin