IGF1 |
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사용 가능한 구조 |
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PDB | 동원체 검색: PDBe RCSB |
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PDB ID 코드 목록 |
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1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS |
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식별자 |
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다른 이름 | IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF |
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외부 ID | OMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1 |
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유전자 위치 (인간) |
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| 염색체 | 12번 염색체[1] |
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| 자리 | 12q23.2 | 시작 | 102,395,874 bp[1] |
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끝 | 102,481,744 bp[1] |
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유전자 위치 (쥐) |
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| 염색체 | 10번 염색체 (쥐)[2] |
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| 자리 | 10 C1|10 43.7 cM | 시작 | 87,694,127 bp[2] |
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끝 | 87,772,904 bp[2] |
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RNA 발현 패턴 |
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Bgee | 인간 | 쥐(동원체) |
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최상위 발현 | - 심장막
- tail of epididymis
- tendon of biceps brachii
- gastric mucosa
- superficial temporal artery
- 정낭
- 요도
- caput epididymis
- 부고환몸통
- 자궁속막
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| 최상위 발현 | - stria vascularis
- 속목동맥
- efferent ductule
- 외경동맥
- 홍채
- left lobe of liver
- 쓸개
- stroma of bone marrow
- genital tubercle
- 백색지방조직
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| 추가 참조 발현 데이터 |
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BioGPS | |
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유전자 온톨로지 |
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분자 함수 | - hormone activity
- insulin receptor binding
- growth factor activity
- integrin binding
- 단백질 결합
- insulin-like growth factor receptor binding
| 세포 성분 | - 세포밖공간
- exocytic vesicle
- insulin-like growth factor binding protein complex
- platelet alpha granule lumen
- insulin-like growth factor ternary complex
- alphav-beta3 integrin-IGF-1-IGF1R complex
- 세포막
- 세포 바깥쪽
| 생물학적 과정 | - positive regulation of transcription regulatory region DNA binding
- skeletal system development
- positive regulation of glucose import
- muscle organ development
- positive regulation of Ras protein signal transduction
- response to heat
- positive regulation of cardiac muscle hypertrophy
- positive regulation of smooth muscle cell migration
- DNA 복제
- positive regulation of insulin-like growth factor receptor signaling pathway
- phosphatidylinositol 3-kinase signaling
- positive regulation of DNA binding
- Ras protein signal transduction
- 세포 증식
- positive regulation of mitotic nuclear division
- positive regulation of trophectodermal cell proliferation
- positive regulation of glycogen biosynthetic process
- positive regulation of fibroblast proliferation
- ERK1 and ERK2 cascade
- negative regulation of extrinsic apoptotic signaling pathway
- cell activation
- negative regulation of oocyte development
- positive regulation of transcription, DNA-templated
- bone mineralization involved in bone maturation
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of MAPK cascade
- proteoglycan biosynthetic process
- positive regulation of activated T cell proliferation
- positive regulation of epithelial cell proliferation
- negative regulation of release of cytochrome c from mitochondria
- protein stabilization
- myotube cell development
- positive regulation of DNA replication
- myoblast proliferation
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
- positive regulation of protein secretion
- positive regulation of glycoprotein biosynthetic process
- 유전자 발현의 조절
- phosphatidylinositol-mediated signaling
- positive regulation of smooth muscle cell proliferation
- 근비대
- protein kinase B signaling
- regulation of multicellular organism growth
- positive regulation of cell migration
- platelet degranulation
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of phosphatidylinositol 3-kinase signaling
- myoblast differentiation
- glycolate metabolic process
- positive regulation of glycolytic process
- negative regulation of smooth muscle cell apoptotic process
- 신호전달
- positive regulation of transcription by RNA polymerase II
- positive regulation of cell growth involved in cardiac muscle cell development
- positive regulation of cell population proliferation
- 조골세포 분화의 상향조절
- activation of protein kinase B activity
- insulin-like growth factor receptor signaling pathway
- 세포자멸사 과정의 하향조절
- positive regulation of tyrosine phosphorylation of STAT protein
- 신호전달 수용체 활성의 조절
- positive regulation of gene expression
- negative regulation of gene expression
- cellular response to amyloid-beta
- positive regulation of vascular associated smooth muscle cell proliferation
- negative regulation of vascular associated smooth muscle cell apoptotic process
- negative regulation of interleukin-1 beta production
- negative regulation of tumor necrosis factor production
- negative regulation of neuroinflammatory response
- negative regulation of amyloid-beta formation
| 출처: Amigo / QuickGO |
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동원체 |
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종 | 인간 | 쥐 |
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앙트레 | | |
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앙상블 | | |
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유니프롯 | | |
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RefSeq (mRNA) | |
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NM_000618 NM_001111283 NM_001111284 NM_001111285 |
| NM_001111274 NM_001111275 NM_001111276 NM_010512 NM_184052
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NM_001314010 |
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RefSeq(단백질) | |
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NP_000609 NP_001104753 NP_001104754 NP_001104755 |
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NP_001104744 NP_001104745 NP_001104746 NP_001300939 NP_034642 |
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위치(UCSC) | Chr 12: 102.4 – 102.48 Mb | Chr 10: 87.69 – 87.77 Mb |
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PubMed 검색 | [3] | [4] |
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위키데이터 |
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