FOXP3 |
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사용 가능한 구조 |
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PDB | 동원체 검색: PDBe RCSB |
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식별자 |
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다른 이름 | FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3 |
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외부 ID | OMIM: 300292 MGI: 1891436 HomoloGene: 8516 GeneCards: FOXP3 |
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유전자 위치 (쥐) |
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| 염색체 | X 염색체 (쥐)[2] |
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| 자리 | X A1.1|X 3.41 cM | 시작 | 7,439,883 bp[2] |
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끝 | 7,461,484 bp[2] |
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RNA 발현 패턴 |
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Bgee | 인간 | 쥐(동원체) |
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최상위 발현 | - 생식샘
- 고환
- tendon of biceps brachii
- 림프절
- 맹장
- 충수
- 혈액
- 편도
- 쓸개
- 과립구
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| 최상위 발현 | - 요도
- male urethra
- 주머니배
- 배
- 인두 (해부학)
- 가슴샘
- 뇌척수막
- tail of embryo
- dentate gyrus of hippocampal formation granule cell
- neural layer of retina
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| 추가 참조 발현 데이터 |
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BioGPS |
| 추가 참조 발현 데이터 |
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유전자 온톨로지 |
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분자 함수 | - sequence-specific DNA binding
- NF-kappaB binding
- transcription corepressor activity
- nucleic acid binding
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- 단백질 결합
- histone deacetylase binding
- DNA-binding transcription factor activity
- NFAT protein binding
- histone acetyltransferase binding
- 금속 이온 결합
- DNA 결합
- protein homodimerization activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
| 세포 성분 | - 세포핵
- intracellular anatomical structure
- 세포질
- 핵질
- 단백질을 포함한 복합체
| 생물학적 과정 | - negative regulation of cell population proliferation
- negative regulation of NF-kappaB transcription factor activity
- B cell homeostasis
- regulation of isotype switching to IgG isotypes
- myeloid cell homeostasis
- negative regulation of inflammatory response
- positive regulation of interleukin-4 production
- regulation of immunoglobulin production
- regulation of transcription by RNA polymerase II
- regulation of T cell anergy
- negative regulation of interleukin-6 production
- tolerance induction to self antigen
- DNA를 주형으로 한 전사의 조절
- negative regulation of DNA-binding transcription factor activity
- positive regulation of T cell tolerance induction
- negative regulation of immune response
- negative regulation of interferon-gamma production
- tolerance induction
- regulatory T cell differentiation
- positive regulation of transcription, DNA-templated
- negative regulation of interleukin-2 production
- positive regulation of histone acetylation
- negative regulation of interleukin-5 production
- negative regulation of chronic inflammatory response
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- positive regulation of transcription by RNA polymerase II
- negative regulation of activated T cell proliferation
- positive regulation of gene expression
- negative regulation of interleukin-4 production
- negative regulation of interleukin-10 production
- negative regulation of tumor necrosis factor production
- T세포 항상성
- negative regulation of CREB transcription factor activity
- negative regulation of T-helper 17 cell differentiation
- T세포 활성화
- positive regulation of immature T cell proliferation in thymus
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of peripheral T cell tolerance induction
- positive regulation of transforming growth factor beta1 production
- negative regulation of transcription, DNA-templated
- negative regulation of lymphocyte proliferation
- negative regulation of histone acetylation
- negative regulation of interleukin-17 production
- response to virus
- negative regulation of histone deacetylation
- CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- negative regulation of T cell proliferation
- chromatin remodeling
- cytokine production
- negative regulation of T cell cytokine production
- negative regulation of isotype switching to IgE isotypes
- T cell receptor signaling pathway
- positive regulation of T cell anergy
- DNA를 주형으로 한 전사
- T cell mediated immunity
- negative regulation of gene expression
- anatomical structure morphogenesis
- regulation of Wnt signaling pathway
- regulation of regulatory T cell differentiation
| 출처: Amigo / QuickGO |
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동원체 |
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종 | 인간 | 쥐 |
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앙트레 | | |
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앙상블 | | |
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유니프롯 | | |
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RefSeq (mRNA) | | |
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NM_001199347 NM_001199348 NM_054039 |
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RefSeq(단백질) | | |
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NP_001186276 NP_001186277 NP_473380 |
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위치(UCSC) | Chr X: 49.25 – 49.27 Mb | Chr X: 7.44 – 7.46 Mb |
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PubMed 검색 | [3] | [4] |
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위키데이터 |
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