UNC84A

Protein-coding gene in the species Homo sapiens
SUN1
Identifiers
AliasesSUN1, UNC84A, Sad1 and UNC84 domain containing 1
External IDsOMIM: 607723; MGI: 1924303; HomoloGene: 11544; GeneCards: SUN1; OMA:SUN1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SUN1
Genomic location for SUN1
Band7p22.3Start816,615 bp[1]
End896,435 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SUN1
Genomic location for SUN1
Band5|5 G2Start139,186,392 bp[2]
End139,235,595 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gastric mucosa

  • mucosa of paranasal sinus

  • right uterine tube

  • body of uterus

  • left ovary

  • bronchial epithelial cell

  • right hemisphere of cerebellum

  • canal of the cervix

  • right ovary
Top expressed in
  • spermatocyte

  • spermatid

  • saccule

  • transitional epithelium of urinary bladder

  • olfactory epithelium

  • superior frontal gyrus

  • ectoderm

  • otic vesicle

  • otic placode

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • lamin binding
  • protein-membrane adaptor activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • nuclear inner membrane
  • integral component of nuclear inner membrane
  • nuclear membrane
  • acrosomal membrane
  • intracellular membrane-bounded organelle
  • nucleus
  • membrane
  • meiotic nuclear membrane microtubule tethering complex
  • nuclear envelope
Biological process
  • response to mechanical stimulus
  • homologous chromosome pairing at meiosis
  • nuclear envelope organization
  • nuclear matrix anchoring at nuclear membrane
  • ossification
  • spermatogenesis
  • nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
  • cell differentiation
  • meiosis
  • centrosome localization
  • meiotic attachment of telomere to nuclear envelope
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23353

77053

Ensembl

ENSG00000164828

ENSMUSG00000036817

UniProt

O94901

Q9D666

RefSeq (mRNA)

NM_025154
NM_001130965
NM_001171944
NM_001171945
NM_001171946

NM_001256115
NM_001256116
NM_001256117
NM_001256118
NM_024451

NM_001359494
NM_001359496

RefSeq (protein)
NP_001124437
NP_001165415
NP_001165416
NP_001165417
NP_079430

NP_001354562
NP_001354563
NP_001354564
NP_001354565
NP_001354566
NP_001354567
NP_001354568
NP_001354569
NP_001354570
NP_001354571
NP_001354572
NP_001354573
NP_001354574
NP_001354575
NP_001354576
NP_001354577
NP_001354578
NP_001354580
NP_001354582
NP_001354584
NP_001354587
NP_001354589
NP_001354591
NP_001354593
NP_001354594
NP_001354595
NP_001354596
NP_001354597
NP_001354598
NP_001354599
NP_001354600
NP_001354601
NP_001354602
NP_001354603
NP_001354604
NP_001354605
NP_001354606
NP_001354607
NP_001354608
NP_001354609
NP_001354610
NP_001354611
NP_001354612
NP_001354613
NP_001354614
NP_001354615
NP_001354616
NP_001354617
NP_001354618
NP_001354619
NP_001354620
NP_001354621
NP_001354622
NP_001354623
NP_001354624
NP_001354625
NP_001354626
NP_001354627
NP_001354628
NP_001354629
NP_001354630
NP_001354631
NP_001354632
NP_001354633
NP_001354634
NP_001354635
NP_001354637

NP_001243044
NP_001243045
NP_001243046
NP_001243047
NP_077771

NP_001346423
NP_001346425

Location (UCSC)Chr 7: 0.82 – 0.9 MbChr 5: 139.19 – 139.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein unc-84 homolog A is a protein that in humans is encoded by the UNC84A gene.[5][6]

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164828 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F (Oct 2001). "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane". Proc Natl Acad Sci U S A. 98 (21): 11943–8. Bibcode:2001PNAS...9811943D. doi:10.1073/pnas.211201898. PMC 59747. PMID 11593002.
  6. ^ a b "Entrez Gene: UNC84A unc-84 homolog A (C. elegans)".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Malone CJ, Fixsen WD, Horvitz HR, Han M (1999). "UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development". Development. 126 (14): 3171–81. doi:10.1242/dev.126.14.3171. PMID 10375507.
  • Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Schirmer EC, Florens L, Guan T, et al. (2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Padmakumar VC, Libotte T, Lu W, et al. (2005). "The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope". J. Cell Sci. 118 (Pt 15): 3419–30. doi:10.1242/jcs.02471. PMID 16079285.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Hasan S, Güttinger S, Mühlhäusser P, et al. (2006). "Nuclear envelope localization of human UNC84A does not require nuclear lamins". FEBS Lett. 580 (5): 1263–8. Bibcode:2006FEBSL.580.1263H. doi:10.1016/j.febslet.2006.01.039. PMID 16445915. S2CID 29434638.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Wang Q, Du X, Cai Z, Greene MI (2006). "Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome". DNA Cell Biol. 25 (10): 554–62. doi:10.1089/dna.2006.25.554. PMID 17132086.
  • Chi YH, Haller K, Peloponese JM, Jeang KT (2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes" (PDF). J. Biol. Chem. 282 (37): 27447–58. doi:10.1074/jbc.M703098200. PMID 17631499. S2CID 44621298.


  • v
  • t
  • e