InterPro Family
Tachykinin receptor |
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Identifiers |
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Symbol | ? |
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InterPro | IPR001681 |
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tachykinin receptor 1 |
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Identifiers |
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Symbol | TACR1 |
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Alt. symbols | TAC1R |
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NCBI gene | 6869 |
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HGNC | 11526 |
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OMIM | 162323 |
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RefSeq | NM_001058 |
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UniProt | P25103 |
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Other data |
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Locus | Chr. 2 p13.1-p12 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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tachykinin receptor 2 |
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Identifiers |
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Symbol | TACR2 |
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Alt. symbols | TAC2R, NKNAR |
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NCBI gene | 6865 |
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HGNC | 11527 |
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OMIM | 162321 |
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RefSeq | NM_001057 |
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UniProt | P21452 |
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Other data |
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Locus | Chr. 10 q11-q21 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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tachykinin receptor 3 |
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Identifiers |
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Symbol | TACR3 |
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NCBI gene | 6870 |
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HGNC | 11528 |
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OMIM | 162332 |
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RefSeq | NM_001059 |
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UniProt | P29371 |
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Other data |
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Locus | Chr. 4 q25 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]
Binding
The genes and receptor ligands are as follows:[2]
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
References
- ^ "Aprepitant". NICE. Retrieved 2020-05-10.
- ^ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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