ST6GALNAC4

Protein-coding gene in the species Homo sapiens

ST6GALNAC4
Identifiers
AliasesST6GALNAC4, IV, SIAT3-C, SIAT3C, SIAT7-D, SIAT7D, ST6GALNACIV, ST6GalNAc, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
External IDsOMIM: 606378; MGI: 1341894; HomoloGene: 7939; GeneCards: ST6GALNAC4; OMA:ST6GALNAC4 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ST6GALNAC4
Genomic location for ST6GALNAC4
Band9q34.11Start127,907,886 bp[1]
End127,917,041 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ST6GALNAC4
Genomic location for ST6GALNAC4
Band2|2 BStart32,477,107 bp[2]
End32,489,710 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • apex of heart

  • upper lobe of left lung

  • spleen

  • right auricle

  • right ovary

  • right coronary artery

  • mucosa of transverse colon

  • left ventricle

  • left coronary artery
Top expressed in
  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • granulocyte

  • muscle of thigh

  • superior frontal gyrus

  • primary visual cortex

  • stroma of bone marrow

  • embryo

  • left colon

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • glycosyltransferase activity
  • sialyltransferase activity
  • (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
  • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • Golgi membrane
Biological process
  • O-glycan processing
  • protein glycosylation
  • oligosaccharide metabolic process
  • glycolipid metabolic process
  • sialylation
  • protein N-linked glycosylation via asparagine
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27090

20448

Ensembl

ENSG00000136840

ENSMUSG00000079442

UniProt

Q9H4F1

Q9R2B6

RefSeq (mRNA)

NM_014403
NM_175039
NM_175040

NM_001276425
NM_011373

RefSeq (protein)

NP_778204
NP_778205

NP_001263354
NP_035503

Location (UCSC)Chr 9: 127.91 – 127.92 MbChr 2: 32.48 – 32.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.[5]

Function

ST6GALNAC4 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The enzyme is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136840 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079442 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4".

Further reading

  • Lanfranchi G, Muraro T, Caldara F, et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Res. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
  • Lee YC, Kaufmann M, Kitazume-Kawaguchi S, et al. (1999). "Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV". J. Biol. Chem. 274 (17): 11958–67. doi:10.1074/jbc.274.17.11958. PMID 10207017.
  • Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Hum. Mol. Genet. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.
  • Harduin-Lepers A, Stokes DC, Steelant WF, et al. (2001). "Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV". Biochem. J. 352 Pt 1 (Pt 1): 37–48. PMC 1221430. PMID 11062056.
  • Moody AM, North SJ, Reinhold B, et al. (2003). "Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction". J. Biol. Chem. 278 (9): 7240–6. doi:10.1074/jbc.M210468200. PMID 12459555.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim SW, Kang NY, Lee SH, et al. (2003). "Genomic structure and promoter analysis of human NeuAc alpha2,3Gal beta1,3GalNAc alpha2,6-sialyltransferase (hST6GalNAc IV) gene". Gene. 305 (1): 113–20. doi:10.1016/S0378-1119(02)01234-9. PMID 12594047.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kang NY, Park YD, Choi HJ, et al. (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells. 18 (2): 157–62. doi:10.1016/S1016-8478(23)13096-2. PMID 15528990.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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