SRPX

Protein-coding gene in the species Homo sapiens
SRPX
Identifiers
AliasesSRPX, DRS, ETX1, HEL-S-83p, SRPX1, sushi repeat containing protein, X-linked, sushi repeat containing protein X-linked
External IDsOMIM: 300187; MGI: 1858306; HomoloGene: 4598; GeneCards: SRPX; OMA:SRPX - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SRPX
Genomic location for SRPX
BandXp11.4Start38,149,336 bp[1]
End38,220,924 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SRPX
Genomic location for SRPX
BandX|X A1.1Start9,904,216 bp[2]
End9,983,948 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • left uterine tube

  • right ventricle

  • subcutaneous adipose tissue

  • decidua

  • parietal pleura

  • tibia

  • lower lobe of lung

  • superficial temporal artery

  • vena cava
Top expressed in
  • calvaria

  • dermis

  • molar

  • lip

  • belly cord

  • lumbar spinal ganglion

  • muscle of thigh

  • lactiferous gland

  • body of femur

  • efferent ductule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • extracellular matrix structural constituent
Cellular component
  • autophagosome
  • cell surface
  • endoplasmic reticulum
  • membrane
  • collagen-containing extracellular matrix
Biological process
  • autophagy
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • phagolysosome assembly
  • cell adhesion
  • negative regulation of cell proliferation involved in contact inhibition
  • response to endoplasmic reticulum stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8406

51795

Ensembl

ENSG00000101955

ENSMUSG00000090084

UniProt

P78539

Q9R0M3

RefSeq (mRNA)

NM_006307
NM_001170750
NM_001170751
NM_001170752

NM_016911
NM_001365087

RefSeq (protein)

NP_001164221
NP_001164222
NP_001164223
NP_006298

NP_058607
NP_001352016

Location (UCSC)Chr X: 38.15 – 38.22 MbChr X: 9.9 – 9.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene.[5][6][7] Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin.[8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101955 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090084 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet. 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID 8634708.
  6. ^ Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet. 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID 8634709.
  7. ^ "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".
  8. ^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

  • Nangaku M, Shankland SJ, Kurokawa K, et al. (1997). "Cloning of a new human gene with short consensus repeats using the EST database". Immunogenetics. 46 (2): 99–103. doi:10.1007/s002510050247. PMID 9162095. S2CID 23621385.
  • Shimakage M, Takami K, Kodama K, et al. (2002). "Expression of drs mRNA in human lung adenocarcinomas". Hum. Pathol. 33 (6): 615–9. doi:10.1053/hupa.2002.125373. PMID 12152160.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
  • Mukaisho K, Suo M, Shimakage M, et al. (2003). "Down-regulation of drs mRNA in colorectal neoplasms". Jpn. J. Cancer Res. 93 (8): 888–93. doi:10.1111/j.1349-7006.2002.tb01334.x. PMC 5927109. PMID 12716466.
  • Kim CJ, Shimakage M, Kushima R, et al. (2003). "Down-regulation of drs mRNA in human prostate carcinomas". Hum. Pathol. 34 (7): 654–7. doi:10.1016/S0046-8177(03)00240-5. PMID 12874760.
  • Tambe Y, Isono T, Haraguchi S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene". Oncogene. 23 (17): 2977–87. doi:10.1038/sj.onc.1207419. PMID 15021917.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.


  • v
  • t
  • e