SLC22A14 |
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Identifiers |
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Aliases | SLC22A14, OCTL2, OCTL4, ORCTL4, solute carrier family 22 member 14 |
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External IDs | OMIM: 604048; MGI: 2685974; HomoloGene: 3530; GeneCards: SLC22A14; OMA:SLC22A14 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3p22.2 | Start | 38,282,294 bp[1] |
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End | 38,318,575 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 F3 | Start | 118,998,523 bp[2] |
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End | 119,194,619 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- pancreatic ductal cell
- lateral nuclear group of thalamus
- left testis
- right testis
- tibialis anterior muscle
- pars reticulata
- male germ cell
- deltoid muscle
- sperm
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| Top expressed in | - spermatid
- seminiferous tubule
- spermatocyte
- proximal tubule
- yolk sac
- white adipose tissue
- spleen
- islet of Langerhans
- human kidney
- right kidney
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - organic cation transmembrane transporter activity
- transmembrane transporter activity
- inorganic anion exchanger activity
- sodium-independent organic anion transmembrane transporter activity
| Cellular component | - integral component of membrane
- integral component of plasma membrane
- membrane
| Biological process | - organic cation transport
- transmembrane transport
- inorganic anion transport
- sodium-independent organic anion transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 3: 38.28 – 38.32 Mb | Chr 9: 119 – 119.19 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.[5]
Function
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144671 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070280 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Solute carrier family 22 member 14". Retrieved 2020-01-19.
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.