SIT1

Protein-coding gene in the species Homo sapiens
SIT1
Identifiers
AliasesSIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1
External IDsOMIM: 604964; MGI: 1889342; HomoloGene: 8694; GeneCards: SIT1; OMA:SIT1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SIT1
Genomic location for SIT1
Band9p13.3Start35,649,295 bp[1]
End35,650,931 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SIT1
Genomic location for SIT1
Band4|4 A5Start43,482,081 bp[2]
End43,483,734 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • lymph node

  • blood

  • spleen

  • thymus

  • appendix

  • superficial temporal artery

  • bone marrow cells

  • tonsil

  • mucosa of transverse colon
Top expressed in
  • thymus

  • mesenteric lymph nodes

  • embryo

  • embryo

  • blood

  • spleen

  • subcutaneous adipose tissue

  • lumbar subsegment of spinal cord

  • granulocyte

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • SH2 domain binding
  • kinase binding
Cellular component
  • integral component of membrane
  • integral component of plasma membrane
  • plasma membrane
  • extracellular exosome
  • membrane
Biological process
  • adaptive immune response
  • immune system process
  • T cell homeostasis
  • regulation of T cell activation
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27240

54390

Ensembl

ENSG00000137078

ENSMUSG00000028460

UniProt

Q9Y3P8

Q8C503

RefSeq (mRNA)

NM_014450

NM_019436

RefSeq (protein)

NP_055265

NP_062309

Location (UCSC)Chr 9: 35.65 – 35.65 MbChr 4: 43.48 – 43.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signaling threshold-regulating transmembrane adapter 1 is a protein that in humans is encoded by the SIT1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137078 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028460 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537. S2CID 34405743.
  6. ^ Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (May 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.
  7. ^ "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".

Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  • Pfrepper KI, Marie-Cardine A, Simeoni L, et al. (2001). "Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)". Eur. J. Immunol. 31 (6): 1825–36. doi:10.1002/1521-4141(200106)31:6<1825::AID-IMMU1825>3.0.CO;2-V. PMID 11433379.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
  • Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. S2CID 340034.


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