SERPINB6

Protein-coding gene in the species Homo sapiens

SERPINB6

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1M37

Identifiers

Aliases

SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6

External IDs

OMIM: 173321; MGI: 103123; HomoloGene: 20956; GeneCards: SERPINB6; OMA:SERPINB6 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p25.2	Start	2,948,159 bp^[1]
Band	6p25.2	End	2,972,165 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 A3.3\|13 14.0 cM	Start	34,101,901 bp^[2]
Band	13 A3.3\|13 14.0 cM	End	34,186,777 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

right uterine tube

body of pancreas

apex of heart

left ovary

right auricle

right ovary

canal of the cervix

right adrenal gland

Top expressed in

stroma of bone marrow

ankle joint

endothelial cell of lymphatic vessel

Ileal epithelium

submandibular gland

esophagus

ovary

skin of external ear

belly cord

left colon

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptidase inhibitor activity protease binding serine-type endopeptidase inhibitor activity
Cellular component	cytoplasm cytosol extracellular exosome nucleus extracellular space plasma membrane secretory granule membrane tertiary granule membrane ficolin-1-rich granule membrane extracellular region collagen-containing extracellular matrix serine protease inhibitor complex
Biological process	negative regulation of peptidase activity hearing cellular response to osmotic stress negative regulation of endopeptidase activity neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5269


20719

Ensembl


ENSG00000124570


ENSMUSG00000060147

UniProt


P35237


Q60854

RefSeq (mRNA)

NM_001195291 NM_001271822 NM_001271823 NM_001271824 NM_001271825
NM_001297699 NM_001297700 NM_004568 NM_001374515 NM_001374516 NM_001374517


NM_001164117 NM_001164118 NM_001243192 NM_009254

RefSeq (protein)

NP_001182220 NP_001258751 NP_001258752 NP_001258753 NP_001258754
NP_001284628 NP_001284629 NP_004559 NP_001361444 NP_001361445 NP_001361446


NP_001157589 NP_001157590 NP_001230121 NP_033280

Location (UCSC)

Chr 6: 2.95 – 2.97 Mb

Chr 13: 34.1 – 34.19 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. Bibcode:1993PNAS...90.9417C. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
^ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835. S2CID 23659776.
^ "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
Coughlin P, Nicholl J, Sun J, et al. (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
Morgenstern KA, Sprecher C, Holth L, et al. (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
Morgenstern KA, Henzel WJ, Baker JB, et al. (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. doi:10.1016/S0021-9258(20)80578-X. PMID 8408007.
Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. doi:10.1016/S0021-9258(18)98385-7. PMID 8486644.
Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
Scott FL, Paddle-Ledinek JE, Cerruti L, et al. (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
Mikolajczyk SD, Millar LS, Marker KM, et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
Saedi MS, Zhu Z, Marker K, et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444. S2CID 2826757.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strik MC, Wolbink A, Wouters D, et al. (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Charron Y, Madani R, Nef S, et al. (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637. S2CID 42438203.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

The MEROPS online database for peptidases and their inhibitors: I04.011
SERPINB6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Serpins

inhibitory