Protein-coding gene in the species Homo sapiens
| RGS13 |
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| Identifiers |
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| Aliases | RGS13, regulator of G protein signaling 13 |
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| External IDs | OMIM: 607190; MGI: 2180585; HomoloGene: 14774; GeneCards: RGS13; OMA:RGS13 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1q31.2 | Start | 192,636,138 bp[1] |
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| End | 192,660,311 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1 F|1 62.56 cM | Start | 144,014,392 bp[2] |
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| End | 144,053,110 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - appendix
- jejunal mucosa
- lymph node
- gallbladder
- mucosa of sigmoid colon
- tonsil
- pancreatic epithelial cell
- mucosa of transverse colon
- duodenum
- rectum
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| | Top expressed in | - cumulus cell
- Paneth cell
- morula
- mesenteric lymph nodes
- jejunum
- epithelium of stomach
- duodenum
- medulla of thymus
- olfactory epithelium
- dermis
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - GTPase activator activity
- GTPase activity
| | Cellular component | - cytoplasm
- cytosol
- nucleus
- plasma membrane
| | Biological process | - G protein-coupled receptor signaling pathway
- negative regulation of signal transduction
- negative regulation of G protein-coupled receptor signaling pathway
- positive regulation of GTPase activity
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 1: 192.64 – 192.66 Mb | Chr 1: 144.01 – 144.05 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.[5][6]
RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.[7]
RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127074 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051079 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
- ^ a b "Entrez Gene: RGS13 regulator of G-protein signalling 13".
- ^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.
Further reading
- Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID 16565322. S2CID 39672919.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Islam TC, Asplund AC, Lindvall JM, Nygren L, Liden J, Kimby E, Christensson B, Smith CI, Sander B (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia. 17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID 12970790. S2CID 4888825.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
- Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–746. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.
