Propanephosphonic acid anhydride
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Preferred IUPAC name 2,4,6-Tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinane-2,4,6-trione | |
Other names PPACA; PPAA; T3P; Propylphosphonic anhydride | |
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ECHA InfoCard | 100.102.078 |
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Properties | |
Chemical formula | C9H21O6P3 |
Molar mass | 318.182 g·mol−1 |
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Hazard statements | H290, H314 |
Precautionary statements | P234, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P390, P404, P405, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Propanephosphonic acid anhydride (PPAA, T3P) is an anhydride of propanephosphonic acid. Its structure is a cyclic trimer, with a phosphorus–oxygen core and propyl groups and additional oxygens attached.[1] The chemical is a useful reagent for peptide synthesis reactions, where it activates the carboxylic acid partner for subsequent reaction with amines. It is commercially available as 50 % solution in DMF or ethyl acetate as a slightly yellow mixture.
References
- ^ "Propanephosphonic acid anhydride". Sigma-Aldrich.
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