Prodilidine
Chemical compound
- none
- 1,2-dimethyl-3-phenylpyrrolidin-3-yl propionate
- 3734-17-6 Y
- 19514
- 18388
- P67JPY18WD
- DTXSID30863261
- Interactive image
- CCC(=O)OC1(CCN(C1C)C)C2=CC=CC=C2
InChI
- InChI=1S/C15H21NO2/c1-4-14(17)18-15(10-11-16(3)12(15)2)13-8-6-5-7-9-13/h5-9,12H,4,10-11H2,1-3H3
- Key:LUKSBMJXPCFBKO-UHFFFAOYSA-N
Prodilidine is an opioid analgesic which is a ring-contracted analogue of prodine. It has around the same analgesic efficacy as codeine, but is only around 1/3 the potency (100mg prodilidine is equivalent to 3mg oral morphine). It has little abuse potential.[1][2][3][4][5]
See also
- Profadol
References
- ^ Fraser HF (January 1964). "Addictiveness of 1,2-dimethyl,3-phenyl,3-propionoxy pyrrolidine hydrochloride (ARC I-O-1)". UNODC Bulletin on Narcotics. 16 (1): 37–43.
- ^ Splitter SR (November 1961). "Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic)". Current Therapeutic Research, Clinical and Experimental. 3: 472–7. PMID 13915874.
- ^ Kissel JW, Albert JR, Boxill GC (December 1961). "The pharmacology of prodilidine hydrochloride, a new analgetic agent". The Journal of Pharmacology and Experimental Therapeutics. 134: 332–40. PMID 14456453.
- ^ Weikel JH, Labudde JA (December 1962). "Absorption, excretion and fate of prodilidine". The Journal of Pharmacology and Experimental Therapeutics. 138: 392–8. PMID 13999550.
- ^ Batterman RC, Mouratoff GJ, Kaufman JE (January 1964). "Prodilidine Hydrochloride: A new moderately potent analgesic". The American Journal of the Medical Sciences. 247: 62–8. doi:10.1097/00000441-196401000-00009. PMID 14106881. S2CID 41209143.
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Opioid receptor modulators
(MOR)
(DOR)
(KOR)
(NOP)
Agonists |
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Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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