Phenol O-methyltransferase

In enzymology, a phenol O-methyltransferase (EC 2.1.1.25) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + phenol ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + anisole

Thus, the two substrates of this enzyme are S-adenosyl methionine and phenol, whereas its two products are S-adenosylhomocysteine and anisole.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phenol O-methyltransferase. This enzyme is also called PMT. This enzyme participates in tyrosine metabolism.

References

• Axelrod J, Daly J (1968). "Phenol-O-methyltransferase". Biochim. Biophys. Acta. 159 (3): 472–8. doi:10.1016/0005-2744(68)90131-9. PMID 5657870.