PTOV1

Protein-coding gene in the species Homo sapiens
PTOV1
Identifiers
AliasesPTOV1, ACID2, PTOV-1, prostate tumor overexpressed 1, extended AT-hook containing adaptor protein, PTOV1 extended AT-hook containing adaptor protein
External IDsOMIM: 610195; MGI: 1933946; HomoloGene: 9687; GeneCards: PTOV1; OMA:PTOV1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PTOV1
Genomic location for PTOV1
Band19q13.33Start49,850,735 bp[1]
End49,860,744 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PTOV1
Genomic location for PTOV1
Band7 B3|7Start44,512,491 bp[2]
End44,519,212 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • right uterine tube

  • right hemisphere of cerebellum

  • anterior pituitary

  • right testis

  • left testis

  • right adrenal gland

  • right adrenal cortex

  • left adrenal cortex
Top expressed in
  • ventricular zone

  • entorhinal cortex

  • perirhinal cortex

  • CA3 field

  • choroid plexus of fourth ventricle

  • lactiferous gland

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • molar
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

53635

84113

Ensembl

ENSG00000104960

ENSMUSG00000038502

UniProt

Q86YD1

Q91VU8

RefSeq (mRNA)
NM_001305105
NM_001305108
NM_017432
NM_001364745
NM_001364747

NM_001364748
NM_001364749
NM_001364750
NM_001394010

NM_133949

RefSeq (protein)
NP_001292034
NP_001292037
NP_059128
NP_001351674
NP_001351676

NP_001351677
NP_001351678
NP_001351679

NP_598710

Location (UCSC)Chr 19: 49.85 – 49.86 MbChr 7: 44.51 – 44.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104960 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038502 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Santamaria A, Fernandez PL, Farre X, Benedit P, Reventos J, Morote J, Paciucci R, Thomson TM (Feb 2003). "PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle". Am J Pathol. 162 (3): 897–905. doi:10.1016/S0002-9440(10)63885-0. PMC 1868092. PMID 12598323.
  6. ^ Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R (Feb 2005). "PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts". Mol Cell Biol. 25 (5): 1900–11. doi:10.1128/MCB.25.5.1900-1911.2005. PMC 549350. PMID 15713644.
  7. ^ "Entrez Gene: PTOV1 prostate tumor overexpressed gene 1".

Further reading

  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Mittler G, Stühler T, Santolin L, et al. (2004). "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". EMBO J. 22 (24): 6494–504. doi:10.1093/emboj/cdg619. PMC 291814. PMID 14657022.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Benedit P, Paciucci R, Thomson TM, et al. (2001). "PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks". Oncogene. 20 (12): 1455–64. doi:10.1038/sj.onc.1204233. PMID 11313889.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


  • v
  • t
  • e