PARD3

Protein-coding gene in the species Homo sapiens
PARD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2KOM

Identifiers
AliasesPARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDsOMIM: 606745; MGI: 2135608; HomoloGene: 10489; GeneCards: PARD3; OMA:PARD3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PARD3
Genomic location for PARD3
Band10p11.22-p11.21Start34,109,560 bp[1]
End34,815,325 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for PARD3
Genomic location for PARD3
Band8 E2|8 74.66 cMStart127,790,643 bp[2]
End128,338,767 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • skin of abdomen

  • skin of leg

  • buccal mucosa cell

  • gingival epithelium

  • nipple

  • mucosa of pharynx

  • Achilles tendon

  • internal globus pallidus

  • gastric mucosa
Top expressed in
  • esophagus

  • lip

  • tail of embryo

  • secondary oocyte

  • conjunctival fornix

  • transitional epithelium of urinary bladder

  • genital tubercle

  • ventricular zone

  • hand

  • cornea
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-3-phosphate binding
  • protein binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • protein phosphatase binding
  • phosphatidylinositol-3,4,5-trisphosphate binding
  • lipid binding
  • identical protein binding
  • phosphatidylinositol binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • cell-cell junction
  • bicellular tight junction
  • plasma membrane
  • axonal growth cone
  • internode region of axon
  • cell junction
  • neuronal cell body
  • cell cortex
  • cytoskeleton
  • endomembrane system
  • adherens junction
  • protein-containing complex
  • apical plasma membrane
  • apical junction complex
Biological process
  • establishment of epithelial cell polarity
  • cell differentiation
  • axonogenesis
  • protein targeting to membrane
  • negative regulation of peptidyl-threonine phosphorylation
  • myelination in peripheral nervous system
  • cell division
  • establishment or maintenance of cell polarity
  • positive regulation of myelination
  • regulation of cellular localization
  • protein kinase C-activating G protein-coupled receptor signaling pathway
  • asymmetric cell division
  • bicellular tight junction assembly
  • cell cycle
  • transforming growth factor beta receptor signaling pathway
  • protein-containing complex assembly
  • microtubule cytoskeleton organization
  • cell adhesion
  • protein localization
  • establishment of cell polarity
  • establishment or maintenance of epithelial cell apical/basal polarity
  • establishment of centrosome localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56288

93742

Ensembl

ENSG00000148498

ENSMUSG00000025812

UniProt

Q8TEW0

Q99NH2

RefSeq (mRNA)
NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789

NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619

NM_001013580
NM_001013581
NM_001122850
NM_033620
NM_001309391

NM_001309392
NM_001363431
NM_001363432

RefSeq (protein)
NP_001171714
NP_001171715
NP_001171716
NP_001171717
NP_001171718

NP_001171719
NP_001171720
NP_001171721
NP_001171722
NP_001171723
NP_062565

NP_001013598
NP_001013599
NP_001116322
NP_001296320
NP_001296321

NP_296369
NP_001350360
NP_001350361

Location (UCSC)Chr 10: 34.11 – 34.82 MbChr 8: 127.79 – 128.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.[5][6]

Function

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM][6]

Interactions

PARD3 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148498 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025812 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
  6. ^ a b "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".
  7. ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
  8. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
  9. ^ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

Further reading

  • Johansson A, Driessens M, Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1". J. Cell Sci. 113 (18): 3267–75. doi:10.1242/jcs.113.18.3267. PMID 10954424.
  • Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
  • Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures". J. Cell Biol. 152 (6): 1183–96. doi:10.1083/jcb.152.6.1183. PMC 2199212. PMID 11257119.
  • Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C." Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
  • Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". EMBO J. 20 (14): 3738–48. doi:10.1093/emboj/20.14.3738. PMC 125258. PMID 11447115.
  • Fang CM, Xu YH (2002). "Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas". Cell Res. 11 (3): 223–9. doi:10.1038/sj.cr.7290090. PMID 11642408.
  • Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
  • Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
  • Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
  • Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946.
  • Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.


  • v
  • t
  • e