Protein-coding gene in the species Homo sapiens
SLC16A7 |
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Identifiers |
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Aliases | SLC16A7, MCT2, solute carrier family 16 member 7 |
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External IDs | OMIM: 603654; MGI: 1330284; HomoloGene: 20990; GeneCards: SLC16A7; OMA:SLC16A7 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q14.1 | Start | 59,596,029 bp[1] |
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End | 59,789,855 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 D3 | Start | 125,055,139 bp[2] |
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End | 125,225,334 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right ventricle
- renal medulla
- vena cava
- pericardium
- sperm
- cardia
- myocardium of left ventricle
- Skeletal muscle tissue of biceps brachii
- superior surface of tongue
- body of tongue
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| Top expressed in | - spermatid
- seminiferous tubule
- spermatocyte
- seminal vesicula
- epithelium of stomach
- right kidney
- transitional epithelium of urinary bladder
- human kidney
- parotid gland
- hair follicle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - pyruvate transmembrane transporter activity
- symporter activity
- pyruvate secondary active transmembrane transporter activity
- lactate transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity
| Cellular component | - integral component of membrane
- plasma membrane
- integral component of plasma membrane
- membrane
| Biological process | - monocarboxylic acid transport
- lactate transmembrane transport
- pyruvate transmembrane transport
- transmembrane transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001270622 NM_001270623 NM_004731 |
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NM_011391 NM_001358496 NM_001358915 |
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RefSeq (protein) | |
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NP_001257551 NP_001257552 NP_004722 |
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NP_035521 NP_001345425 NP_001345844 |
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Location (UCSC) | Chr 12: 59.6 – 59.79 Mb | Chr 10: 125.06 – 125.23 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[5] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid, branched-chain oxo acids derived from [[leucine, valine, and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.
Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.
Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118596 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020102 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.
- ^ Halestrap AP (Jan 2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID 22131303. S2CID 24460891.
- ^ Caruso JP, Koch BJ, Benson PD, Varughese E, Monterey MD, Lee AE, Dave AM, Kiousis S, Sloan AE, Mathupala SP (Feb 2017). "pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma". Neoplasia. 19 (2): 121–134. doi:10.1016/j.neo.2016.12.011. PMC 5238458. PMID 28092823.
Further reading
- Pértega-Gomes N, Vizcaíno JR, Gouveia C, Jerónimo C, Henrique RM, Lopes C, Baltazar F (2013). "Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer". Prostate. 73 (7): 763–9. doi:10.1002/pros.22620. hdl:1822/24037. PMID 23192371. S2CID 5816396.
- Lee I, Lee SJ, Kang WK, Park C (2012). "Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo". Mol. Cancer Ther. 11 (11): 2342–51. doi:10.1158/1535-7163.MCT-12-0488. PMID 22964484.
- Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012). "Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells". Cell Oncol (Dordr). 35 (3): 217–27. doi:10.1007/s13402-012-0081-9. PMC 3396336. PMID 22700320.
- Lauritzen F, Heuser K, de Lanerolle NC, Lee TS, Spencer DD, Kim JH, Gjedde A, Eid T, Bergersen LH (2012). "Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus". Glia. 60 (7): 1172–81. doi:10.1002/glia.22344. PMC 3664041. PMID 22535546.
- Halestrap AP (2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID 22131303. S2CID 24460891.
By group |
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SLC1–10 |
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(1): | |
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(2): | |
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(3): | |
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(4): | |
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(5): | |
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(6): | |
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(7): | |
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(8): | |
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(9): | |
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(10): | |
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| SLC11–20 |
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(11): | - proton coupled metal ion transporter
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(12): | |
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(13): | - human Na+-sulfate/carboxylate cotransporter
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(14): | |
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(15): | - proton oligopeptide cotransporter
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(16): | - monocarboxylate transporter
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(17): | |
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(18): | |
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(19): | |
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(20): | - type III Na+-phosphate cotransporter
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| SLC21–30 |
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(21): | |
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(22): | |
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(23): | - Na+-dependent ascorbic acid transporter
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(24): | |
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(25): | |
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(26): | - multifunctional anion exchanger
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(27): | |
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(28): | - Na+-coupled nucleoside transport (SLC28A1
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(29): | - facilitative nucleoside transporter
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(30): | |
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| SLC31–40 |
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(31): | |
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(32): | |
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(33): | |
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(34): | - type II Na+-phosphate cotransporter
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(35): | - nucleoside-sugar transporter
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-
-
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- SLC35E1
- SLC35E2
- SLC35E3
- SLC35E4
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(36): | |
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(37): | - sugar-phosphate/phosphate exchanger
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(38): | - System A & N, sodium-coupled neutral amino-acid transporter
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(39): | |
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(40): | - basolateral iron transporter
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| SLC41–48 |
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(41): | |
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(42): | |
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(43): | - Na+-independent, system-L like amino-acid transporter
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(44): | |
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(45): | - Putative sugar transporter
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(46): | |
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(47): | |
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(48): | |
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see also solute carrier disorders |
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