Protein-coding gene in the species Homo sapiens
MFSD1 |
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Identifiers |
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Aliases | MFSD1, SMAP4, major facilitator superfamily domain containing 1, Minerva |
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External IDs | MGI: 1914118; HomoloGene: 11228; GeneCards: MFSD1; OMA:MFSD1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3q25.32 | Start | 158,732,198 bp[1] |
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End | 158,829,719 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 E1 | Start | 67,490,074 bp[2] |
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End | 67,511,570 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- trabecular bone
- palpebral conjunctiva
- visceral pleura
- epithelium of nasopharynx
- parietal pleura
- gums
- skin of hip
- parotid gland
- gingival epithelium
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| Top expressed in | - stroma of bone marrow
- right kidney
- yolk sac
- human kidney
- proximal tubule
- olfactory epithelium
- primitive streak
- lactiferous gland
- submandibular gland
- calvaria
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001167903 NM_001289406 NM_001289407 NM_022736 |
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RefSeq (protein) | |
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NP_001161375 NP_001276335 NP_001276336 NP_073573 |
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Location (UCSC) | Chr 3: 158.73 – 158.83 Mb | Chr 3: 67.49 – 67.51 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan.[5] It is an Atypical solute carrier.[6]
It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes [6] and lysosomes.[7][8]
HGNC:25874
MFSD1 belongs to AMTF6.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118855 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027775 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
- ^ a b Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
- ^ Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.
- ^ Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.
- ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.