M-RIP

Protein-coding gene in the species Homo sapiens

MPRIP
Identifiers
AliasesMPRIP, M-RIP, MRIP, RHOIP3, RIP3, p116Rip, myosin phosphatase Rho interacting protein
External IDsOMIM: 612935; MGI: 1349438; HomoloGene: 9034; GeneCards: MPRIP; OMA:MPRIP - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MPRIP
Genomic location for MPRIP
Band17p11.2Start17,042,457 bp[1]
End17,217,679 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MPRIP
Genomic location for MPRIP
Band11|11 B1.3Start59,552,131 bp[2]
End59,671,686 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • popliteal artery

  • tibial arteries

  • sural nerve

  • right coronary artery

  • amniotic fluid

  • olfactory bulb

  • saphenous vein

  • body of uterus

  • ganglionic eminence

  • buccal mucosa cell
Top expressed in
  • spermatid

  • CA3 field

  • lactiferous gland

  • ankle joint

  • entorhinal cortex

  • choroid plexus of fourth ventricle

  • perirhinal cortex

  • left lung

  • seminiferous tubule

  • right lung
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • actin binding
  • protein binding
  • cadherin binding
Cellular component
  • cytoskeleton
  • focal adhesion
  • actin cytoskeleton
  • cytoplasm
  • cytosol
Biological process
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23164

26936

Ensembl

ENSG00000133030

ENSMUSG00000005417

UniProt

Q6WCQ1

P97434

RefSeq (mRNA)

NM_015134
NM_201274
NM_001364716

NM_012027
NM_201245
NM_001368931

RefSeq (protein)

NP_055949
NP_958431
NP_001351645

NP_036157
NP_957697
NP_001355860

Location (UCSC)Chr 17: 17.04 – 17.22 MbChr 11: 59.55 – 59.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene.[5][6]

Interactions

M-RIP has been shown to interact with RHOA.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133030 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005417 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. ^ "Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein".
  7. ^ Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (Jun 1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7): 1603–13. doi:10.1083/jcb.137.7.1603. PMC 2137826. PMID 9199174.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7): 1603–13. doi:10.1083/jcb.137.7.1603. PMC 2137826. PMID 9199174.
  • Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–93. doi:10.1074/jbc.M305622200. PMID 14506264.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Mulder J, Ariaens A, van den Boomen D, Moolenaar WH (2005). "p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis". Mol. Biol. Cell. 15 (12): 5516–27. doi:10.1091/mbc.E04-04-0275. PMC 532030. PMID 15469989.
  • Koga Y, Ikebe M (2005). "p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA". J. Biol. Chem. 280 (6): 4983–91. doi:10.1074/jbc.M410909200. PMID 15545284.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Surks HK, Riddick N, Ohtani K (2006). "M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells". J. Biol. Chem. 280 (52): 42543–51. doi:10.1074/jbc.M506863200. PMID 16257966.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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