Liprin-alpha-1

Protein-coding gene in the species Homo sapiens

PPFIA1

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
1N7F

Identifiers

Aliases

PPFIA1, LIP.1, LIP1, LIPRIN, PTPRF interacting protein alpha 1

External IDs

OMIM: 611054; MGI: 1924750; HomoloGene: 20802; GeneCards: PPFIA1; OMA:PPFIA1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.3	Start	70,270,690 bp^[1]
Band	11q13.3	End	70,385,312 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F5	Start	144,030,495 bp^[2]
Band	7\|7 F5	End	144,107,466 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

oocyte

secondary oocyte

buccal mucosa cell

sperm

Achilles tendon

endothelial cell

Epithelium of choroid plexus

tibia

visceral pleura

Top expressed in

zygote

secondary oocyte

genital tubercle

tail of embryo

primary oocyte

ventricular zone

superior cervical ganglion

esophagus

hair follicle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding signal transducer activity
Cellular component	presynaptic active zone focal adhesion cytoplasm cytosol axon dendrite protein-containing complex
Biological process	cell-matrix adhesion negative regulation of stress fiber assembly signal transduction negative regulation of protein localization to plasma membrane neurotransmitter secretion glutamate secretion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8500


233977

Ensembl


ENSG00000131626 ENSG00000288198


ENSMUSG00000037519

UniProt


Q13136


n/a

RefSeq (mRNA)


NM_003626 NM_177423 NM_001378006


NM_001033319 NM_001195086

RefSeq (protein)


NP_003617 NP_803172 NP_001364935


n/a

Location (UCSC)

Chr 11: 70.27 – 70.39 Mb

Chr 7: 144.03 – 144.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[7]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

References

^ ^a ^b ^c ENSG00000288198 GRCh38: Ensembl release 89: ENSG00000131626, ENSG00000288198 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–2838. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
^ ^a ^b ^c ^d Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153.
^ ^a ^b "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".
^ ^a ^b ^c Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
^ ^a ^b Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b ^c Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.