FAAH2 : Wikipedia, the free encyclopedia

FAAH2

Protein-coding gene in humans

FAAH2

Identifiers

Aliases

FAAH2, AMDD, fatty acid amide hydrolase 2

External IDs

OMIM: 300654; HomoloGene: 45263; GeneCards: FAAH2; OMA:FAAH2 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp11.21	Start	57,286,706 bp^[1]
Band	Xp11.21	End	57,489,193 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

body of pancreas

right lobe of liver

olfactory zone of nasal mucosa

pituitary gland

anterior pituitary

islet of Langerhans

skin of abdomen

skin of leg

minor salivary glands

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hydrolase activity fatty acid amide hydrolase activity
Cellular component	integral component of membrane lipid droplet membrane
Biological process	arachidonic acid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


158584


n/a

Ensembl


ENSG00000165591


n/a

UniProt


Q6GMR7


n/a

RefSeq (mRNA)


NM_174912 NM_001353840 NM_001353841


n/a

RefSeq (protein)


NP_777572 NP_001340769 NP_001340770


n/a

Location (UCSC)

Chr X: 57.29 – 57.49 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Fatty acid amide hydrolase 2 or FAAH2 is a member of the serine hydrolase family of enzymes.^[3]

Fatty acid amide hydrolase 2 degrades endocannabinoids and defects in this enzyme have been associated with neurologic and psychiatric disorders.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165591 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF (December 2006). "A second fatty acid amide hydrolase with variable distribution among placental mammals". The Journal of Biological Chemistry. 281 (48): 36569–78. doi:10.1074/jbc.M606646200. PMID 17015445.
^ Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, et al. (March 2015). "Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms". Orphanet Journal of Rare Diseases. 10: 38. doi:10.1186/s13023-015-0248-3. PMC 4423390. PMID 25885783.