Class I PI 3-kinases
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Class IA PI 3-kinases
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).
There are three catalytic subunits that are classified as class IA PI 3-kinases:[citation needed]
- p110α
- p110β
- p110δ
There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:[citation needed]
- p85α and p85β
- p55α and p55γ
- p50α
Class IB PI 3-kinases
Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).
The only known class IB PI 3-kinase catalytic subunit is p110γ.
There are two known regulatory subunits for p110γ:
- p101
- p84/ p87PIKAP.
See also
- Phosphoinositide 3-kinase#Class I
- Phosphoinositide 3-kinase inhibitor
References
- Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment". Endocr. Relat. Cancer. 8 (3): 237–48. CiteSeerX 10.1.1.324.8135. doi:10.1677/erc.0.0080237. PMID 11566615. S2CID 568427. Archived from the original on 2008-05-21. Retrieved 2008-09-24.
- Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733.
- Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases" (PDF). Exp. Cell Res. 253 (1): 239–54. doi:10.1006/excr.1999.4701. PMID 10579926. Archived from the original (PDF) on January 2, 2006.
- v
- t
- e
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor | |
---|---|
2.7.2: COOH acceptor | |
2.7.3: N acceptor | |
2.7.4: PO4 acceptor |
(P2O7)
(PO4-nucleoside)
Polymerase |
| ||||
---|---|---|---|---|---|
Phosphorolytic 3' to 5' exoribonuclease | |||||
Nucleotidyltransferase | |||||
Guanylyltransferase | |||||
Other |
Phosphatidyltransferases | |
---|---|
Glycosyl-1-phosphotransferase |
(PO4; protein acceptor)
2.7.10: protein-tyrosine |
|
---|---|
2.7.11: protein-serine/threonine |
|
2.7.12: protein-dual-specificity |
|
2.7.13: protein-histidine |
This cell biology article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e