CLDN15

Protein-coding gene in the species Homo sapiens
CLDN15
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4P79

Identifiers
AliasesCLDN15, claudin 15
External IDsOMIM: 615778; MGI: 1913103; HomoloGene: 8646; GeneCards: CLDN15; OMA:CLDN15 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CLDN15
Genomic location for CLDN15
Band7q22.1Start101,232,092 bp[1]
End101,238,820 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CLDN15
Genomic location for CLDN15
Band5|5 G2Start136,995,470 bp[2]
End137,004,712 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • duodenum

  • mucosa of ileum

  • germinal epithelium

  • mucosa of transverse colon

  • granulocyte

  • parietal pleura

  • right lobe of liver

  • left uterine tube

  • spleen
Top expressed in
  • duodenum

  • crypt of lieberkuhn of small intestine

  • intestinal villus

  • granulocyte

  • jejunum

  • Paneth cell

  • epithelium of small intestine

  • ileum

  • left colon

  • oocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural molecule activity
  • identical protein binding
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • lateral plasma membrane
  • membrane
  • bicellular tight junction
Biological process
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
  • ion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

24146

60363

Ensembl

ENSG00000106404

ENSMUSG00000001739

UniProt

P56746

Q9Z0S5

RefSeq (mRNA)

NM_138429
NM_001185080
NM_014343

NM_021719

RefSeq (protein)

NP_001172009
NP_055158

NP_068365

Location (UCSC)Chr 7: 101.23 – 101.24 MbChr 5: 137 – 137 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene.[5] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.[6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106404 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001739 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CLDN15 claudin 15".
  6. ^ Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards | CLD15 Protein | CLD15 Antibody". www.genecards.org. Retrieved 2017-04-14.

External links

Further reading

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
  • Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
  • Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi:10.1681/ASN.V134875. PMID 11912246.
  • Colegio OR, Van Itallie CM, McCrea HJ, et al. (2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol., Cell Physiol. 283 (1): C142–7. doi:10.1152/ajpcell.00038.2002. PMID 12055082. S2CID 9555118.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Van Itallie CM, Fanning AS, Anderson JM (2003). "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. Physiol. Renal Physiol. 285 (6): F1078–84. doi:10.1152/ajprenal.00116.2003. PMID 13129853.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.


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