CITED1

Protein-coding gene in humans
CITED1
Identifiers
AliasesCITED1, MSG1, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
External IDsOMIM: 300149; MGI: 108023; HomoloGene: 3057; GeneCards: CITED1; OMA:CITED1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CITED1
Genomic location for CITED1
BandXq13.1Start72,301,638 bp[1]
End72,307,187 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for CITED1
Genomic location for CITED1
BandX D|X 45.25 cMStart101,290,987 bp[2]
End101,295,787 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • anterior pituitary

  • hypothalamus

  • testicle

  • prefrontal cortex

  • anterior cingulate cortex

  • amygdala

  • dorsolateral prefrontal cortex

  • superior frontal gyrus
Top expressed in
  • yolk sac

  • morula

  • tail of embryo

  • reticular formation

  • atrium

  • paraxial mesoderm

  • lactiferous gland

  • raphe nuclei

  • endocardium

  • endocardial cushion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transcription coactivator activity
  • co-SMAD binding
  • protein homodimerization activity
  • DNA-binding transcription factor activity
  • chromatin binding
  • LBD domain binding
  • protein C-terminus binding
  • protein binding
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
  • nucleoplasm
Biological process
  • negative regulation of neuron apoptotic process
  • response to transforming growth factor beta
  • positive regulation of transforming growth factor beta receptor signaling pathway
  • cell differentiation
  • response to cytokine
  • melanin biosynthetic process
  • spongiotrophoblast layer development
  • response to interleukin-1
  • regulation of transcription, DNA-templated
  • SMAD protein signal transduction
  • response to interleukin-4
  • response to interferon-gamma
  • response to interleukin-6
  • placenta development
  • regulation of transcription by RNA polymerase II
  • response to interleukin-2
  • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
  • labyrinthine layer development
  • response to interleukin-11
  • negative regulation of Wnt signaling pathway
  • embryonic axis specification
  • negative regulation of osteoblast differentiation
  • transcription, DNA-templated
  • response to estrogen
  • vasculogenesis
  • positive regulation of transcription, DNA-templated
  • response to insulin
  • multicellular organism development
  • response to lipopolysaccharide
  • branching involved in ureteric bud morphogenesis
  • brain development
  • positive regulation of gene expression
  • response to parathyroid hormone
  • nucleocytoplasmic transport
  • pigmentation
  • response to cAMP
  • cell population proliferation
  • metanephros development
  • melanocyte differentiation
  • negative regulation of transcription, DNA-templated
  • response to interleukin-9
  • transforming growth factor beta receptor signaling pathway
  • mesenchymal to epithelial transition
  • apoptotic process
  • positive regulation of transcription by RNA polymerase II
  • regulation of apoptotic process
  • transcription by RNA polymerase II
  • positive regulation of mesenchymal stem cell proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4435

12705

Ensembl

ENSG00000125931

ENSMUSG00000051159

UniProt

Q99966

P97769

RefSeq (mRNA)

NM_001144885
NM_001144886
NM_001144887
NM_004143

NM_001276466
NM_001276473
NM_001276474
NM_007709

RefSeq (protein)

NP_001138357
NP_001138358
NP_001138359
NP_004134

NP_001263395
NP_001263402
NP_001263403
NP_031735

Location (UCSC)Chr X: 72.3 – 72.31 MbChr X: 101.29 – 101.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.[5][6][7]

Interactions

CITED1 has been shown to interact with HSPA8[8] and EP300.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125931 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051159 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
  6. ^ Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
  7. ^ "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
  8. ^ a b Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12). UNITED STATES: 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

External links

Further reading

  • Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
  • Li H, Ahmed NU, Fenner MH, et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
  • Shioda T, Lechleider RJ, Dunwoodie SL, et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. Bibcode:1998PNAS...95.9785S. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553.
  • Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand). 45 (7): 1075–82. PMID 10644012.
  • Yahata T, de Caestecker MP, Lechleider RJ, et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
  • Ahmed NU, Shioda T, Coser KR, et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
  • Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
  • Yahata T, Shao W, Endoh H, et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164.
  • Bragança J, Swingler T, Marques FI, et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shi G, Boyle SC, Sparrow DB, et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
  • Lovvorn HN, Westrup J, Opperman S, et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia. 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162.


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