CFLAR |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
3H11, 3H13, 2N5R |
|
|
Identifiers |
---|
Aliases | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP |
---|
External IDs | OMIM: 603599; MGI: 1336166; HomoloGene: 7652; GeneCards: CFLAR; OMA:CFLAR - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 2 (human)[1] |
---|
| Band | 2q33.1 | Start | 201,116,154 bp[1] |
---|
End | 201,176,687 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 1 (mouse)[2] |
---|
| Band | 1 C1.3|1 29.16 cM | Start | 58,750,667 bp[2] |
---|
End | 58,798,043 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - right lung
- apex of heart
- upper lobe of left lung
- right auricle
- left ventricle
- epithelium of colon
- blood
- granulocyte
- gastrocnemius muscle
- bone marrow cells
|
| Top expressed in | - granulocyte
- right kidney
- ascending aorta
- aortic valve
- proximal tubule
- right lung
- right lung lobe
- ciliary body
- thymus
- lateral recess
|
| More reference expression data |
|
---|
BioGPS |
| More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - cysteine-type peptidase activity
- protein binding
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- enzyme activator activity
- cysteine-type endopeptidase activity
- peptidase activator activity
- protein heterodimerization activity
- protease binding
- death receptor binding
- protein-containing complex binding
- cysteine-type endopeptidase activity involved in apoptotic process
| Cellular component | - cytosol
- CD95 death-inducing signaling complex
- ripoptosome
- death-inducing signaling complex
- membrane raft
- cytoplasm
| Biological process | - regulation of apoptotic process
- execution phase of apoptosis
- negative regulation of apoptotic process
- proteolysis
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- regulation of necroptotic process
- regulation of extrinsic apoptotic signaling pathway via death domain receptors
- viral process
- apoptotic process
- positive regulation of catalytic activity
- response to hypoxia
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of neuron projection development
- cellular response to insulin stimulus
- response to testosterone
- positive regulation of ERK1 and ERK2 cascade
- cellular response to epidermal growth factor stimulus
- cellular response to estradiol stimulus
- cellular response to hypoxia
- cellular response to dexamethasone stimulus
- cellular response to nitric oxide
- positive regulation of glomerular mesangial cell proliferation
- positive regulation of extracellular matrix organization
- negative regulation of reactive oxygen species biosynthetic process
- negative regulation of cellular response to transforming growth factor beta stimulus
- negative regulation of hepatocyte apoptotic process
- negative regulation of epithelial cell apoptotic process
- positive regulation of hepatocyte proliferation
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- skeletal muscle tissue development
- positive regulation of peptidase activity
- skeletal muscle atrophy
- regulation of skeletal muscle satellite cell proliferation
- skeletal myofibril assembly
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- skeletal muscle tissue regeneration
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of necroptotic process
- negative regulation of myoblast fusion
- negative regulation of extrinsic apoptotic signaling pathway
- response to bacterium
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517
|
---|
NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879 NM_001351590 NM_001351591 NM_001351592 NM_001351593 NM_001351594 |
| NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653
|
---|
NM_001355056 |
|
---|
RefSeq (protein) | NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446
|
---|
NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870 NP_001338519 NP_001338520 NP_001338521 NP_001338522 NP_001338523 |
| NP_001276633 NP_001280733 NP_001280734 NP_033935 NP_997536
|
---|
NP_001341985 |
|
---|
Location (UCSC) | Chr 2: 201.12 – 201.18 Mb | Chr 1: 58.75 – 58.8 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|