Anisindione
Chemical compound
- none
- 2-(4-methoxyphenyl)indene-1,3-dione
- 117-37-3 Y
- 2197
- 6960
- DB01125 Y
- 2112 Y
- S747T1ERAJ
- D07457 Y
- CHEBI:133809 Y
- ChEMBL712 Y
- DTXSID3022611
- Interactive image
- O=C2c1ccccc1C(=O)C2c3ccc(OC)cc3
InChI
- InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3 Y
- Key:XRCFXMGQEVUZFC-UHFFFAOYSA-N Y
Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.[1]
References
- ^ Matschinske J, Salgado-Albarrán M, Sadegh S, Bongiovanni D, Baumbach J, Blumenthal DB (November 2020). "Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex". Assay and Drug Development Technologies. 18 (8): 348–355. doi:10.1089/adt.2020.1010. PMC 7703307. PMID 33164550.
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Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Glycoprotein IIb/IIIa inhibitors |
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ADP receptor/P2Y12 inhibitors |
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Prostaglandin analogue (PGI2) | |
COX inhibitors | |
Thromboxane inhibitors | |
Phosphodiesterase inhibitors | |
Other |
Vitamin K antagonists (inhibit II, VII, IX, X) | |||||
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Factor Xa inhibitors (with some II inhibition) |
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Direct thrombin (IIa) inhibitors |
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Other |
fibrinolytics
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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