ARFGEF2

Protein-coding gene in the species Homo sapiens
ARFGEF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3L8N, 3SWV

Identifiers
AliasesARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
External IDsOMIM: 605371; MGI: 2139354; HomoloGene: 111880; GeneCards: ARFGEF2; OMA:ARFGEF2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ARFGEF2
Genomic location for ARFGEF2
Band20q13.13Start48,921,711 bp[1]
End49,036,693 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ARFGEF2
Genomic location for ARFGEF2
Band2|2 H3Start166,647,508 bp[2]
End166,739,972 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • jejunal mucosa

  • parotid gland

  • Epithelium of choroid plexus

  • corpus epididymis

  • skin of thigh

  • cardia

  • mucosa of sigmoid colon

  • secondary oocyte

  • retinal pigment epithelium
Top expressed in
  • retinal pigment epithelium

  • lacrimal gland

  • secondary oocyte

  • submandibular gland

  • Epithelium of choroid plexus

  • stroma of bone marrow

  • superior cervical ganglion

  • epithelium of stomach

  • interventricular septum

  • medial vestibular nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • guanyl-nucleotide exchange factor activity
  • GABA receptor binding
  • myosin binding
  • protein binding
  • protein kinase A regulatory subunit binding
Cellular component
  • cytoplasm
  • recycling endosome
  • cytosol
  • endosome
  • Golgi apparatus
  • cell projection
  • membrane
  • Golgi membrane
  • dendritic spine
  • synapse
  • microtubule organizing center
  • cell junction
  • trans-Golgi network
  • dendrite
  • symmetric synapse
  • asymmetric synapse
  • perinuclear region of cytoplasm
  • cytoskeleton
  • cytoplasmic vesicle
  • axonemal microtubule
Biological process
  • endomembrane system organization
  • intracellular signal transduction
  • regulation of ARF protein signal transduction
  • endosome organization
  • receptor recycling
  • positive regulation of tumor necrosis factor production
  • protein transport
  • Golgi to plasma membrane transport
  • exocytosis
  • transport
  • regulation of molecular function
  • vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10564

99371

Ensembl

ENSG00000124198

ENSMUSG00000074582

UniProt

Q9Y6D5

A2A5R2

RefSeq (mRNA)

NM_006420

NM_001085495

RefSeq (protein)

NP_006411

NP_001078964

Location (UCSC)Chr 20: 48.92 – 49.04 MbChr 2: 166.65 – 166.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.[5][6]

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.[6]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,[7] PRKAR1A[8] and PRKAR2A.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124198 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074582 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
  6. ^ a b "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".
  7. ^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
  8. ^ a b Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.

Further reading

  • Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
  • Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
  • Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology. Vol. 345. pp. 397–404. doi:10.1016/S0076-6879(02)45032-X. ISBN 9780121822460. PMID 11665623.
  • Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K (Mar 2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.
  • Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K (Jun 2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
  • Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
  • Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA (Jan 2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nature Genetics. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2784–9. Bibcode:2005PNAS..102.2784X. doi:10.1073/pnas.0409871102. PMC 549493. PMID 15705715.
  • Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V (Jan 2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251. S2CID 16527134.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ (Mar 2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". The Journal of Biological Chemistry. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.
  • Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. Bibcode:2007PNAS..104.3201K. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629.


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