3,3-Dimethyl-1-butanol
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Names | |
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Preferred IUPAC name 3,3-Dimethylbutan-1-ol | |
Other names 3,3-Dimethyl-1-butanol | |
Identifiers | |
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3D model (JSmol) |
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ChemSpider |
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ECHA InfoCard | 100.009.884 ![]() |
PubChem CID |
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InChI
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Properties | |
Chemical formula | C6H14O |
Molar mass | 102.177 g·mol−1 |
Density | 0.844 g/cm3 @ Temp: 15 °C |
Melting point | -60 °C |
Boiling point | 143 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
3,3-Dimethyl-1-butanol (DMB) is a structural analog of choline.[1]
Effects
DMB inhibits microbial trimethylamine (TMA) formation in mice and in human feces, thereby reducing plasma trimethylamine N-oxide (TMAO) levels after choline or carnitine supplementation.[1] It consequently inhibited choline-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in mice without alterations in circulating cholesterol levels.[1]
While mice placed on a choline supplemented diet showed an increase in the proportions of the bacterial taxon Clostridiales in the gut, DMB induced a decrease in the proportions of this taxon.[1]
Mice showed no evidence of toxicity to chronic (16-week) DMB exposure.[1][2]
Occurrence
DMB is found in some balsamic vinegars, red wines, and some cold-pressed extra virgin olive oils and grape seed oils.[1]
References
- ^ a b c d e f Wang, Zeneng; Roberts, Adam B.; Buffa, Jennifer A.; Levison, Bruce S.; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K.; DiDonato, Anthony J.; Fu, Xiaoming; Hazen, Jennie E.; Krajcik, Daniel; DiDonato, Joseph A.; Lusis, Aldons J.; Hazen, Stanley L. (December 2015). "Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis". Cell. 163 (7): 1585–1595. doi:10.1016/j.cell.2015.11.055. PMC 4871610. PMID 26687352.
- ^ EP0081050A1, Kaufhold, Manfred Dr, "Process for the production of pure neohexanol", issued 1983-06-15