April (16-11) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 3 | April 1 | @ Athletics | 2–1 | Matsuzaka (1–0) | Blanton (0–1) | Papelbon (2) | 36,067 | 2–1 | 4 | April 2 | @ Athletics | 5–0 | Lester (1–1) | Embree (0–1) | | 21,625 | 3–1 | 5 | April 4 | @ Blue Jays | 6–3 | Marcum (1–0) | Aardsma (0–1) | Accardo (2) | 50,171 | 3–2 | 6 | April 5 | @ Blue Jays | 10–2 | Litsch (1–0) | Buchholz (0–1) | | 35,238 | 3–3 | 7 | April 6 | @ Blue Jays | 7–4 | Halladay (1–1) | Beckett (0–1) | Accardo (3) | 30,114 | 3–4 | 8 | April 8 | Tigers | 5–0 | Matsuzaka (2–0) | Rogers (0–2) | | 36,567 | 4–4 | 9 | April 9 | Tigers | 7–2 | Bonderman (1–1) | Lester (1–2) | | 37,190 | 4–5 | 10 | April 10 | Tigers | 12–6 | Wakefield (1–0) | Robertson (0–1) | Papelbon (3) | 37,612 | 5–5 | 11 | April 11 | Yankees | 4–1 | Wang (3–0) | Timlin (0–1) | | 37,624 | 5–6 | 12 | April 12 | Yankees | 4–3 | Beckett (1–1) | Mussina (1–2) | Papelbon (4) | 37,461 | 6–6 | 13 | April 13 | Yankees | 8–5 | Matsuzaka (3–0) | Hughes (0–2) | | 37,876 | 7–6 | 14 | April 14 | @ Indians | 6–4 | Timlin (1–1 | Borowski (0–2) | Papelbon (5) | 21,802 | 8–6 | 15 | April 15 | @ Indians | 5–3 | Aardsma (1–1) | Lewis (0–1) | Okajima (1) | 25,135 | 9–6 | 16 | April 16 | @ Yankees | 15–9 | Hawkins (1–0) | Tavárez (0–1) | Bruney (1) | 54,667 | 9–7 | 17 | April 17 | @ Yankees | 7–5 | Beckett (2–1) | Mussina (1–3) | | 55,088 | 10–7 | 18 | April 18 | Rangers | 11–3 | Matsuzaka (4–0) | Mendoza (0–2) | | 37,902 | 11–7 | 19 | April 19 | Rangers | 5–3 | López (1–0) | Benoit (1–1) | Papelbon (6) | 37,958 | 12–7 | 20 | April 20 | Rangers | 6–5 | Wakefield (2–0) | Wilson (0–1) | Papelbon (7) | 37,480 | 13–7 | 21 | April 21 | Rangers | 8–3 | Buchholz (1–1) | Nippert (1–2) | | 37,539 | 14–7 | 22 | April 22 | Angels | 7–6 | Timlin (2–1) | Oliver (1–1) | Papelbon (8) | 37,982 | 15–7 | 23 | April 23 | Angels | 6–4 | Garland (3–2) | Hansen (0–1) | Rodríguez (8) | 38,172 | 15–8 | 24 | April 24 | Angels | 7–5 | Saunders (4–0) | Delcarmen (0–1) | Rodríguez (9) | 36,848 | 15–9 | 25 | April 25 | @ Rays | 5–4 | Dohmann (1–0) | Timlin (2–2) | | 30,290 | 15–10 | 26 | April 26 | @ Rays | 2–1 | Dohmann (2–0) | Buchholz (1–2) | Percival (5) | 36,048 | 15–11 | 27 | April 27 | @ Rays | 3–0 | Shields (3–1) | Beckett (2–2) | | 32,363 | 15–12 | 28 | April 29 | Blue Jays | 1–0 | Papelbon (1–0) | Halladay (2–4) | | 37,215 | 16–12 | 29 | April 30 | Blue Jays | 2–1 | Papelbon (2–0) | Downs(0–1) | | 37,710 | 17–12 | May (17-12) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 30 | May 1 | Blue Jays | 3–0 | Burnett (3–2) | Wakefield (2–1) | Ryan (3) | 37,821 | 17–13 | 31 | May 2 | Rays | 7–3 | Buchholz (2–2) | Jackson (2–3) | | 37,541 | 18–13 | 32 | May 3 | Rays | 12–4 | Beckett (3–2) | Shields (3–2) | | 37,700 | 19–13 | 33 | May 4 | Rays | 7–3 | Lester (2–2) | Kazmir (0–1) | Papelbon (9) | 37,091 | 20–13 | 34 | May 5 | @ Tigers | 6–3 | Matsuzaka (5–0) | Bonderman (2–3) | Papelbon (10) | 39,478 | 21–13 | 35 | May 6 | @ Tigers | 5–0 | Wakefield (3–1) | Robertson (1–4) | | 38,564 | 22–13 | 36 | May 7 | @ Tigers | 10–9 | Jones (1–0) | Papelbon (2–1) | | 38,062 | 22–14 | 37 | May 8 | @ Tigers | 5–1 | Beckett (4–2) | Verlander (1–6) | | 38,592 | 23–14 | 38 | May 9 | @ Twins | 7–6 | Crain (1–1) | Papelbon (2–2) | | 25,477 | 23–15 | 39 | May 10 | @ Twins | 5–2 | Matsuzaka (6–0) | Perkins (0–1) | Papelbon (11) | 33,839 | 24–15 | 40 | May 11 | @ Twins | 9–8 | Blackburn (3–2) | Wakefield (3–2) | Nathan (12) | 26,511 | 24–16 | 41 | May 12 | @ Twins | 7–3 | Hernández (6–1) | Buchholz (2–3) | | 18,782 | 24–17 | 42 | May 13 | @ Orioles | 5–4 | Guthrie (2–3) | Beckett (4–3) | Sherrill (14) | 38,768 | 24–18 | 43 | May 14 | @ Orioles | 6–3 | Cabrera (4–1) | Hansen (0–2) | Sherrill (15) | 28,939 | 24–19 | – | May 16 | Brewers | Postponed (rain) Rescheduled for May 17 | 44 | May 17 | Brewers | 5–3 | Matsuzaka (7–0) | Suppan (2–3) | Papelbon (12) | 37,409 | 25–19 | 45 | May 17 | Brewers | 7–6 | Hansen (1–2) | Torres (3–1) | Timlin (1) | 37,847 | 26–19 | 46 | May 18 | Brewers | 11–7 | Beckett (5–3) | Villanueva (2–5) | | 37,204 | 27–19 | 47 | May 19 | Royals | 7–0 | Lester (3–2) (no-hitter) | Hochevar (3–3) | | 37,746 | 28–19 | 48 | May 20 | Royals | 2–1 | Masterson (1–0) | Meche (3–6) | Papelbon (13) | 37,486 | 29–19 | 49 | May 21 | Royals | 6–3 | Colón (1–0) | Tomko (2–5) | | 37,674 | 30–19 | 50 | May 22 | Royals | 11–8 | Matsuzaka (8–0) | Bannister (4–6) | Papelbon (14) | 37,613 | 31–19 | 51 | May 23 | @ Athletics | 8–3 | Harden (3–0) | Wakefield (3–3) | | 29,057 | 31–20 | 52 | May 24 | @ Athletics | 3–0 | Duchscherer (4–3) | Beckett (5–4) | Street (10) | 33,468 | 31–21 | 53 | May 25 | @ Athletics | 6–3 | Blanton (3–6) | Lester (3–3) | Street (11) | 33,067 | 31–22 | 54 | May 26 | @ Mariners | 5–3 | Colón (2–0) | Hernández (2–5) | | 35,818 | 32–22 | 55 | May 27 | @ Mariners | 4–3 | Putz (2–3) | Timlin (2–3) | | 30,758 | 32–23 | 56 | May 28 | @ Mariners | 1–0 | Bédard (4–3) | Wakefield (3–4) | Putz (6) | 30,752 | 32–24 | 57 | May 30 | @ Orioles | 5–2 (13) | Timlin (3–3) | Bradford (2–2) | Papelbon (15) | 46,199 | 33–24 | 58 | May 31 | @ Orioles | 6–3 | Aardsma (2–1) | Cormier (0–2) | Papelbon (16) | 48,281 | 34–24 | June (16-11) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 59 | June 1 | @ Orioles | 9–4 | Colón (3–0) | Burres (4–5) | | 45,031 | 35–24 | 60 | June 2 | @ Orioles | 6–3 | Johnson (1–2) | Okajima (1–1) | Sherrill (18) | 25,711 | 35–25 | 61 | June 3 | Rays | 7–4 | Masterson (2–0) | Garza (4–2) | Papelbon (17) | 37,823 | 36–25 | 62 | June 4 | Rays | 5–1 | Beckett (6–4) | Jackson (3–5) | | 37,474 | 37–25 | 63 | June 5 | Rays | 7–1 | Lester (4–3) | Shields (4–4) | | 37,639 | 38–25 | 64 | June 6 | Mariners | 8–0 | Hernández (4–5) | Colón (3–1) | | 37,757 | 38–26 | 65 | June 7 | Mariners | 11–3 | Wakefield (4–4) | Batista (3–7) | | 37,443 | 39–26 | 66 | June 8 | Mariners | 2–1 | Masterson (3–0) | Green (1–2) | Papelbon (18) | 37,198 | 40–26 | 67 | June 10 | Orioles | 10–6 | Sarfate (4–1) | Okajima (1–2) | | 37,858 | 40–27 | 68 | June 11 | Orioles | 6–3 | Colón (4–1) | Olson (5–2) | Papelbon (19) | 38,180 | 41–27 | 69 | June 12 | Orioles | 9–2 | Lester (5–3) | Guthrie (3–7) | | 38,139 | 42–27 | 70 | June 13 | @ Reds | 3–1 | Harang (3–9) | Masterson (3–1) | Cordero (13) | 38,855 | 42–28 | 71 | June 14 | @ Reds | 6–4 (10) | Papelbon (3–2) | Lincoln (0–2) | Hansen (1) | 39,154 | 43–28 | 72 | June 15 | @ Reds | 9–0 | Beckett (7–4) | Bailey (0–3) | | 39,958 | 44–28 | 73 | June 16 | @ Phillies | 8–2 | Hamels (7–4) | Colón (4–2) | | 45,026 | 44–29 | 74 | June 17 | @ Phillies | 3–0 | Lester (6–3) | Moyer (7–4) | Papelbon (20) | 45,160 | 45–29 | 75 | June 18 | @ Phillies | 7–4 | Masterson (4–1) | Kendrick (6–3) | Papelbon (21) | 45,187 | 46–29 | 76 | June 20 | Cardinals | 5–4 | Lohse (9–2) | Wakefield (4–5) | Franklin (10) | 37,671 | 46–30 | 77 | June 21 | Cardinals | 9–3 | Boggs (2–0) | Matsuzaka (8–1) | | 37,227 | 46–31 | 78 | June 22 | Cardinals | 5–3 (13) | López (2–0) | Parisi (0–3) | | 37,085 | 47–31 | 79 | June 23 | D-backs | 2–1 | Haren (8–4) | Beckett (7–5) | Lyon (16) | 37,694 | 47–32 | 80 | June 24 | D-backs | 5–4 | Smith (1–0) | Qualls (1–6) | Papelbon (22) | 37,867 | 48–32 | 81 | June 25 | D-backs | 5–0 | Wakefield (5–5) | Johnson (4–6) | Papelbon (23) | 37,924 | 49–32 | 82 | June 27 | @ Astros | 6–1 | Matsuzaka (9–1) | Hernández (0–1) | Papelbon (24) | 42,237 | 50–32 | 83 | June 28 | @ Astros | 11–10 | Brocail (3–3) | Delcarmen (0–2) | Valverde (20) | 43,073 | 50–33 | 84 | June 29 | @ Astros | 3–2 | Brocail (4–3) | Aardsma (2–2) | Valverde (21) | 42,066 | 50–34 | 85 | June 30 | @ Rays | 5–4 | Shields (6–5) | Masterson (4–2) | Howell (2) | 34,145 | 50–35 | July (11-13) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 86 | July 1 | @ Rays | 3–1 | Garza (7–4) | Wakefield (5–6) | Balfour (2) | 31,112 | 50–36 | 87 | July 2 | @ Rays | 7–6 | Glover (1–2) | Hansen (1–3) | Wheeler (3) | 36,048 | 50–37 | 88 | July 3 | @ Yankees | 7–0 | Lester (7–3) | Pettitte (9–6) | | 54,677 | 51–37 | 89 | July 4 | @ Yankees | 6–4 | Beckett (8–5) | Rasner (4–7) | Papelbon (25) | 55,130 | 52–37 | 90 | July 5 | @ Yankees | 2–1 | Mussina (11–6) | Masterson (4–3) | Rivera (23) | 54,920 | 52–38 | 91 | July 6 | @ Yankees | 5–4 (10) | Rivera (3–3) | Papelbon (3–3) | | 54,922 | 52–39 | 92 | July 7 | Twins | 1–0 | Okajima (2–2) | Bass (3–3) | Papelbon (26) | 37,912 | 53–39 | 93 | July 8 | Twins | 6–5 | Aardsma (3–2) | Guerrier (4–4) | Papelbon (27) | 37,925 | 54–39 | 94 | July 9 | Twins | 18–5 | Beckett (9–5) | Hernández (9–6) | | 37,470 | 55–39 | 95 | July 11 | Orioles | 7–3 | Burres (7–5) | Buchholz (2–4) | Sherrill (28) | 37,779 | 55–40 | 96 | July 12 | Orioles | 12–1 | Wakefield (6–6) | Liz (3–2) | | 37,539 | 56–40 | 97 | July 13 | Orioles | 2–1 | Matsuzaka (10–1) | Cabrera (6–5) | Papelbon (28) | 37,344 | 57–40 | 98 | July 18 | @ Angels | 11–3 | Lackey (7–2) | Buchholz (2–5) | | 44,260 | 57–41 | 99 | July 19 | @ Angels | 4–2 | Arredondo (4–0) | Beckett (9–6) | Rodríguez (39) | 44,005 | 57–42 | 100 | July 20 | @ Angels | 5–3 | Oliver (3–1) | Wakefield (6–7) | Rodríguez (40) | 44,164 | 57–43 | 101 | July 21 | @ Mariners | 4–0 | Lester (8–3) | Washburn (4–9) | Papelbon (29) | 37,861 | 58–43 | 102 | July 22 | @ Mariners | 4–2 | Matsuzaka (11–1) | Dickey (2–5) | Papelbon (30) | 38,425 | 59–43 | 103 | July 23 | @ Mariners | 6–3 (13) | Papelbon (4–3) | Green 2–3) | Hansen (2) | 43,231 | 60–43 | 104 | July 25 | Yankees | 1–0 | Chamberlain (3–3) | Beckett (9–7) | Rivera (26) | 37,744 | 60–44 | 105 | July 26 | Yankees | 10–3 | Pettitte (12–7) | Wakefield (6–8) | | 37,225 | 60–45 | 106 | July 27 | Yankees | 9–2 | Lester (9–3) | Ponson (6–2) | | 37,688 | 61–45 | 107 | July 28 | Angels | 7–5 | Weaver (9–8) | Matsuzaka (11–2) | Rodríguez (44) | 37,830 | 61–46 | 108 | July 29 | Angels | 6–2 | Lackey (9–2) | Buchholz (2–6) | | 38,110 | 61–47 | 109 | July 30 | Angels | 9–2 | Saunders (14–5) | Beckett (9–8) | | 38,042 | 61–48 | August (18-9) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 110 | August 1 | Athletics | 2–1 (12) | Timlin (4–3) | Embree (1–4) | | 37,832 | 62–48 | 111 | August 2 | Athletics | 12–2 | Lester (10–3) | Eveland (7–8) | | 37,838 | 63–48 | 112 | August 3 | Athletics | 5–2 | Matsuzaka (12–2) | Braden (2–2) | Papelbon (31) | 37,317 | 64–48 | 113 | August 4 | @ Royals | 4–3 | Meche (10–9) | Buchholz (2–7) | Soria (32) | 24,378 | 64–49 | 114 | August 5 | @ Royals | 8–2 | Beckett (10–8) | Bannister (7–10) | | 22,069 | 65–49 | 115 | August 6 | @ Royals | 8–2 | Wakefield (7–8) | Hochevar (6–10) | | 24,294 | 66–49 | 116 | August 8 | @ White Sox | 5–3 | Buehrle (9–10) | Lester (10–4) | Jenks (23) | 38,621 | 66–50 | 117 | August 9 | @ White Sox | 6–2 | Matsuzaka (13–2) | Logan (2–3) | | 39,243 | 67–50 | 118 | August 10 | @ White Sox | 6–5 | Floyd (12–6) | Buchholz (2–8) | Jenks (24) | 39,008 | 67–51 | 119 | August 11 | @ White Sox | 5–1 | Beckett (11–8) | Danks (9–5) | | 32,634 | 68–51 | 120 | August 12 | Rangers | 19–17 | Okajima (3–2) | Francisco (2–4) | Papelbon (32) | 38,004 | 69–51 | 121 | August 13 | Rangers | 8–4 | Lester (11–4) | Mendoza (3–6) | | 37,876 | 70–51 | 122 | August 14 | Rangers | 10–0 | Matsuzaka (14–2) | Hunter (0–2) | | 37,856 | 71–51 | – | August 15 | Blue Jays | Postponed (rain) Rescheduled for September 13 | 123 | August 16 | Blue Jays | 4–1 | Halladay (14–9) | Byrd (7–11) | | 37,834 | 71–52 | 124 | August 17 | Blue Jays | 15–4 | Marcum (8–5) | Beckett (11–9) | | 37,415 | 71–53 | 125 | August 18 | @ Orioles | 6–3 | Lester (12–4) | Guthrie (10–9) | Papelbon (33) | 40,429 | 72–53 | 126 | August 19 | @ Orioles | 7–2 | Matsuzaka (15–2) | Cabrera (8–8) | | 48,515 | 73–53 | 127 | August 20 | @ Orioles | 11–6 | Waters (2–0) | Buchholz (2–9) | | 33,364 | 73–54 | 128 | August 22 | @ Blue Jays | 8–4 | Byrd (8–11) | Marcum (8–6) | | 40,181 | 74–54 | 129 | August 23 | @ Blue Jays | 11–0 | Litsch (9–7) | Lester (12–5) | | 44,986 | 74–55 | 130 | August 24 | @ Blue Jays | 6–5 (11) | Papelbon (5–3) | League (0–2) | Delcarmen (1) | 44,521 | 75–55 | 131 | August 26 | @ Yankees | 7–3 | Wakefield (8–8) | Pettitte (13–10) | Papelbon (34) | 55,058 | 76–55 | 132 | August 27 | @ Yankees | 11–3 | Byrd (9–11) | Ponson (7–5) | | 55,027 | 77–55 | 133 | August 28 | @ Yankees | 3–2 | Rivera (5–5) | Masterson (4–4) | | 55,092 | 77–56 | 134 | August 29 | White Sox | 8–0 | Matsuzaka (16–2) | Vázquez (10–12) | | 37,755 | 78–56 | 135 | August 30 | White Sox | 8–2 | Bowden (1–0) | Buehrle (11–11) | | 37,751 | 79–56 | 136 | August 31 | White Sox | 4–2 | Floyd (15–6) | Wakefield (8–9) | Jenks (12) | 37,751 | 79–57 | September (16-10) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 137 | September 1 | Orioles | 7–4 | Byrd (10–11) | Olson (8–7) | Papelbon (35) | 37,565 | 80–57 | 138 | September 2 | Orioles | 14–2 | Lester (13–5) | Liz (5–4) | | 37,710 | 81–57 | 139 | September 3 | Orioles | 5–4 | Masterson (5–4) | Miller (0–1) | | 37,373 | 82–57 | 140 | September 5 | @ Rangers | 8–1 | Beckett (12–9) | Millwood (9–8) | | 30,264 | 83–57 | 141 | September 6 | @ Rangers | 15–8 | Harrison (7–3) | Wakefield (8–10) | | 38,208 | 83–58 | 142 | September 7 | @ Rangers | 7–2 | Byrd (11–11) | McCarthy (1–1) | | 28,644 | 84–58 | 143 | September 8 | Rays | 3–0 | Lester (14–5) | Jackson (11–10) | Papelbon (36) | 37,662 | 85–58 | 144 | September 9 | Rays | 5–4 | Wheeler (4–5) | Papelbon (5–4) | Percival (28) | 37,573 | 85–59 | 145 | September 10 | Rays | 4–2 (14) | Miller (2–0) | Timlin (4–4) | Hammel (1) | 38,114 | 85–60 | 146 | September 12 | Blue Jays | 7–0 | Wakefield (9–10) | Purcey (3–6) | | 37,398 | 86–60 | 147 | September 13 | Blue Jays | 8–1 | Burnett (18–10) | Byrd (11–12) | | 37,341 | 86–61 | 148 | September 13 | Blue Jays | 7–5 | Masterson (6–4) | Downs (0–3) | Papelbon (37) | 37,846 | 87–61 | 149 | September 14 | Blue Jays | 4–3 | Lester (15–5) | Halladay (18–11) | Papelbon (38) | 37,007 | 88–61 | 150 | September 15 | @ Rays | 13–5 | Matsuzaka (17–2) | Kazmir (11–7) | | 29,772 | 89–61 | 151 | September 16 | @ Rays | 2–1 | Wheeler (5–5) | Masterson (6–5) | | 32,079 | 89–62 | 152 | September 17 | @ Rays | 10–3 | Balfour (5–2) | Wakefield (9–11) | | 36,048 | 89–63 | 153 | September 19 | @ Blue Jays | 4–3 | Delcarmen (1–2) | Tallet (1–2) | Papelbon (39) | 34,982 | 90–63 | 154 | September 20 | @ Blue Jays | 6–3 | Halladay (19–11) | Lester (15–6) | Ryan (32) | 40,554 | 90–64 | 155 | September 21 | @ Blue Jays | 3–0 | Matsuzaka (18–2) | Richmond (0–3) | Papelbon (40) | 38,814 | 91–64 | 156 | September 22 | Indians | 4–3 | Jackson (1–3) | Beckett (12–10) | Lewis (12) | 37,828 | 91–65 | 157 | September 23 | Indians | 5–4 | Wakefield (10–11) | Lee (22–3) | Papelbon (41) | 37,882 | 92–65 | 158 | September 24 | Indians | 5–4 | Aardsma (4–2) | Pérez (4–4) | Delcarmen (2) | 37,719 | 93–65 | 159 | September 25 | Indians | 6–1 | Lester (16–6) | Sowers (4–9) | | 37,726 | 94–65 | 160 | September 26 | Yankees | 19–8 | Robertson (4–0) | Pauley (0–1) | | 37,301 | 94–66 | – | September 27 | Yankees | Postponed (rain) Rescheduled for September 28 | 161 | September 28 | Yankees | 6–2 | Mussina (20–9) | Matsuzaka (18–3) | Rivera (39) | 37,091 | 94–67 | 162 | September 28 | Yankees | 4–3 (10) | Hansack (1–0) | Veras (5–3) | | 37,440 | 95–67 | |